In molecular biology, the ars operon is an operon found in several bacterial taxon. It is required for the detoxification of arsenate, arsenite, and antimonite.[1] This system transports arsenite and antimonite out of the cell. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite before it is extruded. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance. ArsC is an approximately 150-residue arsenate reductase that uses reduced glutathione (GSH) to convert arsenate to arsenite with a redox active cysteine residue in the active site. ArsC forms an active quaternary complex with GSH, arsenate, and glutaredoxin 1 (Grx1). The three ligands must be present simultaneously for reduction to occur.[2]
^Carlin A, Shi W, Dey S, Rosen BP (February 1995). "The ars operon of Escherichia coli confers arsenical and antimonial resistance". J. Bacteriol. 177 (4): 981–6. doi:10.1128/jb.177.4.981-986.1995. PMC 176692. PMID 7860609.
^Liu J, Rosen BP (August 1997). "Ligand interactions of the ArsC arsenate reductase". J. Biol. Chem. 272 (34): 21084–9. doi:10.1074/jbc.272.34.21084. PMID 9261111.
In molecular biology, the arsoperon is an operon found in several bacterial taxon. It is required for the detoxification of arsenate, arsenite, and antimonite...
ARSD or ArsD may refer to: ARS-D, the Alliance for the Re-liberation of Somalia ArsD, a trans-acting repressor of the arsRDABC operon that confers resistance...
to a given substance. For example, arsenic can be detected using the arsoperon found in several bacterial taxon. An important part of a biosensor is...
"The role of arsenic-thiol interactions in metalloregulation of the arsoperon". J Biol Chem. 271 (16): 9291–9297. doi:10.1074/jbc.271.16.9291. PMID 8621591...
Based on operon analyses, ARC3 homologues may function either as secondary carriers or as primary active transporters, similarly to the ArsB and ArsAB families...
Arsenite resistance (Ars) efflux pumps of bacteria may consist of two proteins, ArsB (TC# 2.A.45.1.1; the integral membrane constituent with twelve transmembrane...
Lin. These two scientists designed a genetic screen using the sdh-lacZ operon in a Δlac strain of E. coli. It was shown that mutations in arcA and arcB...
complete their life cycle with an inactivated plcR. It is half of a two-gene operon along with the heptapeptide papR. papR is part of quorum sensing in B. thuringiensis...
"Ferroplasma acidarmanus": new insights into the structure and evolution of the ars genes" (PDF). Extremophiles. 7 (2). Springer-Verlag: 123–30. doi:10.1007/s00792-002-0303-6...
as enzymes that catalyze steps in the same metabolic pathway into novel operons, and large differences in tRNA genes and their aminoacyl tRNA synthetases...
proteins, which comprise NADH dehydrogenase I, are encoded within the nuo operon, and are homologous to mitochondrial complex I subunits. The antiporter-like...
Global Information