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Arginine and proline metabolism information


Arginine and proline metabolism is one of the central pathways for the biosynthesis of the amino acids arginine and proline from glutamate. The pathways linking arginine, glutamate, and proline are bidirectional. Thus, the net utilization or production of these amino acids is highly dependent on cell type and developmental stage. Altered proline metabolism has been linked to metastasis formation in breast cancer.[1]

  1. ^ Elia, Ilaria; Broekaert, Dorien; Christen, Stefan; Boon, Ruben; Radaelli, Enrico; Orth, Martin F.; Verfaillie, Catherine; Grünewald, Thomas G. P.; Fendt, Sarah-Maria (2017). "Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells". Nature Communications. 8: 15267. Bibcode:2017NatCo...815267E. doi:10.1038/ncomms15267. PMC 5437289. PMID 28492237.

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Arginine and proline metabolism

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Arginine and proline metabolism is one of the central pathways for the biosynthesis of the amino acids arginine and proline from glutamate. The pathways...

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Arginine deiminase

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in arginine and proline metabolism. This enzyme is widely expressed in bacteria, including streptococcus and actinomyces. The bacterial arginine deiminase...

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Arginine kinase

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This enzyme participates in arginine and proline metabolism. The systematic name of this enzyme class is ATP:L-arginine Nω-phosphotransferase Other names...

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Carbohydrate metabolism

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Carbohydrate metabolism is the whole of the biochemical processes responsible for the metabolic formation, breakdown, and interconversion of carbohydrates...

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Creatinase

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in arginine and proline metabolism. As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1CHM and 1KP0...

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Proline racemase

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is proline racemase. This enzyme participates in arginine and proline metabolism. These enzymes catalyse the interconversion of L- and D-proline in bacteria...

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Creatininase

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also called creatinine hydrolase. This enzyme participates in arginine and proline metabolism. Creatininase from Pseudomonas putida has a core structure...

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Arginine

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linking arginine, glutamine, and proline are bidirectional. Thus, the net use or production of these amino acids is highly dependent on cell type and developmental...

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Urea cycle

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and is catalyzed by argininosuccinate synthetase. Argininosuccinate undergoes cleavage by argininosuccinase to form arginine and fumarate. Arginine is...

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Phthalates

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found in the study's urine samples. The disruption of the arginine and proline metabolism associated with this elevated MnBP concentration as a result of...

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Protein metabolism

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Protein metabolism denotes the various biochemical processes responsible for the synthesis of proteins and amino acids (anabolism), and the breakdown...

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Lipid metabolism

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Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown and storage of fats for energy and the synthesis of structural...

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Metabolism

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Metabolism (/məˈtæbəlɪzəm/, from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms. The three main functions...

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Carbamate kinase

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phosphokinase, and carbamyl phosphokinase. This enzyme participates in 4 metabolic pathways: purine metabolism, glutamate metabolism, arginine and proline metabolism...

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Proline

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proline can be synthesized from diethyl malonate and acrylonitrile: Hyperprolinemia Inborn error of metabolism Prolidase deficiency Prolinol "Proline"...

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Guanidinoacetate kinase

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also called glycocyamine kinase. This enzyme participates in arginine and proline metabolism. HOBSON GE, REES KR (1957). "The annelid phosphokinases". Biochem...

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Succinylornithine transaminase

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AstC, SOAT, and 2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase. This enzyme participates in arginine and proline metabolism. Vander Wauven...

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Succinylglutamate desuccinylase

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N2-succinylglutamate desuccinylase, SGDS, and AstE. This enzyme participates in arginine and proline metabolism. Vander Wauven C, Stalon V (1985). "Occurrence...

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Creatinine deaminase

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use include creatinine hydrolase, and creatinine desiminase. This enzyme participates in arginine and proline metabolism. Szulmajster J (October 1958). "Bacterial...

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