Chemical compound
Arbaclofen placarbil Pregnancy category ATC code Legal status
(3R )-3-(4-chlorophenyl)-4-[[[(1S )-2-methyl-1-[(2-methylpropanoyl)oxy]propoxy]carbonyl]amino]butanoic acid
CAS Number PubChem CID ChemSpider UNII KEGG D08861 Y ChEMBL ChEMBL2107312 Y CompTox Dashboard (EPA ) DTXSID40233754 ECHA InfoCard 100.221.150 Formula C 19 H 26 Cl N O 6 Molar mass 399.87 g·mol−1 3D model (JSmol)
CC(C)C(=O)O[C@@H](OC(=O)NC[C@H](CC(=O)O)c1ccc(Cl)cc1)C(C)C
InChI=1S/C19H26ClNO6/c1-11(2)17(24)26-18(12(3)4)27-19(25)21-10-14(9-16(22)23)13-5-7-15(20)8-6-13/h5-8,11-12,14,18H,9-10H2,1-4H3,(H,21,25)(H,22,23)/t14-,18-/m0/s1
Key:JXTAALBWJQJLGN-KSSFIOAISA-N
Arbaclofen placarbil ( ar-BAK -loh-fen plə-KAR -bil , also known as XP19986 ) is a prodrug of R -baclofen. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis; however, in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials.[1]
It is being developed as an addiction medicine to treat alcoholism. [2] It is also studied as a potential therapeutic for some autistic subjects.[3]
^ "XenoPort Reports Top-Line Results of Phase 3 Trial of Arbaclofen Placarbil for Spasticity in Multiple Sclerosis Patients". XenoPort, Inc . May 20, 2013. Archived from the original on 2013-12-02. Retrieved 2013-06-03 .
^ Anderson E (3 July 2020). "Pill that replaces alcohol aims to end 'glass of wine' craving". The i newspaper . Associated Newspapers Limited.
^ Huang Q, Pereira AC, Velthuis H, Wong NM, Ellis CL, Ponteduro FM, et al. (January 2022). "GABAB receptor modulation of visual sensory processing in adults with and without autism spectrum disorder" (PDF) . Science Translational Medicine . 14 (626): eabg7859. doi:10.1126/scitranslmed.abg7859. PMID 34985973. S2CID 245771626.
Last Update: 2023-09-18T12:12:14Z
Arbaclofen placarbil (/ɑːrˈbækloʊfɛn pləˈkɑːrbɪl/ ar-BAK-loh-fen plə-KAR-bil, also known as XP19986) is a prodrug of R-baclofen. Arbaclofen placarbil ...
Word Count : 210
Last Update: 2024-05-26T12:14:13Z
Agonists: 1,4-Butanediol 3-APPA 4-Fluorophenibut Aceburic acid Arbaclofen Arbaclofen placarbil Baclofen BL-1020 GABA Gabamide GABOB GBL GHB GHBAL GHV GVL...
Word Count : 3204
Last Update: 2024-05-19T05:25:24Z
Agonists: 1,4-Butanediol 3-APPA 4-Fluorophenibut Aceburic acid Arbaclofen Arbaclofen placarbil Baclofen BL-1020 GABA Gabamide GABOB GBL GHB GHBAL GHV GVL...
Word Count : 2651
Last Update: 2024-01-06T08:13:02Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 3266
Last Update: 2024-01-27T04:40:48Z
Agonists: 1,4-Butanediol 3-APPA 4-Fluorophenibut Aceburic acid Arbaclofen Arbaclofen placarbil Baclofen BL-1020 GABA Gabamide GABOB GBL GHB GHBAL GHV GVL...
Word Count : 754
Last Update: 2024-04-27T08:45:14Z
Agonists: 1,4-Butanediol 3-APPA 4-Fluorophenibut Aceburic acid Arbaclofen Arbaclofen placarbil Baclofen BL-1020 GABA Gabamide GABOB GBL GHB GHBAL GHV GVL...
Word Count : 2443
Last Update: 2024-03-04T15:42:44Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 847
Last Update: 2024-03-11T19:39:04Z
Agonists: 1,4-Butanediol 3-APPA 4-Fluorophenibut Aceburic acid Arbaclofen Arbaclofen placarbil Baclofen BL-1020 GABA Gabamide GABOB GBL GHB GHBAL GHV GVL...
Word Count : 740
Last Update: 2022-09-25T05:44:18Z
Agonists: 1,4-Butanediol 3-APPA 4-Fluorophenibut Aceburic acid Arbaclofen Arbaclofen placarbil Baclofen BL-1020 GABA Gabamide GABOB GBL GHB GHBAL GHV GVL...
Word Count : 520
Last Update: 2024-05-06T13:39:36Z
Agonists: 1,4-Butanediol 3-APPA 4-Fluorophenibut Aceburic acid Arbaclofen Arbaclofen placarbil Baclofen BL-1020 GABA Gabamide GABOB GBL GHB GHBAL GHV GVL...
Word Count : 3164
Last Update: 2024-03-23T13:08:24Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 2632
Last Update: 2024-02-09T05:50:51Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 2164
Last Update: 2024-04-18T02:58:42Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 2273
Last Update: 2024-04-29T02:44:40Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 3967
Last Update: 2024-05-24T22:06:01Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 8001
Last Update: 2024-03-12T21:16:56Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 2467
Last Update: 2024-03-30T16:10:51Z
Agonists: 1,4-Butanediol 3-APPA 4-Fluorophenibut Aceburic acid Arbaclofen Arbaclofen placarbil Baclofen BL-1020 GABA Gabamide GABOB GBL GHB GHBAL GHV GVL...
Word Count : 1632
Last Update: 2024-02-09T06:06:26Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 1321
Last Update: 2024-05-12T19:07:45Z
Agonists: 1,4-Butanediol 3-APPA 4-Fluorophenibut Aceburic acid Arbaclofen Arbaclofen placarbil Baclofen BL-1020 GABA Gabamide GABOB GBL GHB GHBAL GHV GVL...
Word Count : 10497
Last Update: 2024-03-31T02:54:51Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 1481
Last Update: 2024-01-18T05:50:59Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 382
Last Update: 2024-05-19T01:39:22Z
Agonists: 1,4-Butanediol 3-APPA 4-Fluorophenibut Aceburic acid Arbaclofen Arbaclofen placarbil Baclofen BL-1020 GABA Gabamide GABOB GBL GHB GHBAL GHV GVL...
Word Count : 776
Last Update: 2024-01-12T06:08:56Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 1132
Last Update: 2024-04-03T04:44:03Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 1454
Last Update: 2024-01-01T23:42:27Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 2027
Last Update: 2024-05-24T06:46:01Z
α2δ subunit-selective (gabapentinoids): 4-Methylpregabalin Arbaclofen Arbaclofen placarbil Atagabalin Baclofen Gabapentin Gabapentin enacarbil Imagabalin...
Word Count : 2038