Angiotensin II receptor type 2 information

AGTR2
Identifiers
Aliases	AGTR2, AT2, ATGR2, MRX88, Angiotensin II receptor type 2
External IDs	OMIM: 300034; MGI: 87966; HomoloGene: 20172; GeneCards: AGTR2; OMA:AGTR2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	116,174,974 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	21,355,403 bp
RNA expression pattern
	Top expressed in
	smooth muscle tissue; ; tibia; ; lower lobe of lung; ; cartilage tissue; ; left uterine tube; ; visceral pleura; ; right lung; ; upper lobe of lung; ; upper lobe of left lung; ; superficial temporal artery;
	Top expressed in
	dermis; ; efferent ductule; ; vas deferens; ; human fetus; ; superior cervical ganglion; ; internal carotid artery; ; Gonadal ridge; ; external carotid artery; ; belly cord; ; corneal stroma;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; receptor antagonist activity; peptide hormone binding; G protein-coupled receptor activity; protein binding; angiotensin type II receptor activity; transcription factor binding;
Cellular component	integral component of membrane; membrane; perinuclear region of cytoplasm; plasma membrane; integral component of plasma membrane; extracellular region;
Biological process	regulation of metanephros size; positive regulation of metanephric glomerulus development; intracellular signal transduction; kidney morphogenesis; regulation of apoptotic process; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of nitric-oxide synthase activity; signal transduction; dopamine biosynthetic process; positive regulation of nitric oxide biosynthetic process; negative regulation of norepinephrine secretion; cellular sodium ion homeostasis; renin-angiotensin regulation of aldosterone production; cellular response to dexamethasone stimulus; brain development; angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure; brain renin-angiotensin system; regulation of blood pressure; kidney development; negative regulation of icosanoid secretion; positive regulation of extrinsic apoptotic signaling pathway; regulation of systemic arterial blood pressure by circulatory renin-angiotensin; aldosterone secretion; G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; positive regulation of cell population proliferation; positive regulation of transcription, DNA-templated; negative regulation of blood vessel endothelial cell migration; negative regulation of neurotrophin TRK receptor signaling pathway; response to organonitrogen compound; cerebellar cortex development; negative regulation of fibroblast proliferation; blood vessel remodeling; cell growth involved in cardiac muscle cell development; negative regulation of heart rate; negative regulation of cell growth; positive regulation of phosphoprotein phosphatase activity; exploration behavior; inflammatory response; positive regulation of renal sodium excretion; cell surface receptor signaling pathway; nitric oxide mediated signal transduction; angiotensin-activated signaling pathway; extracellular negative regulation of signal transduction; vasodilation; blood vessel diameter maintenance; G protein-coupled receptor signaling pathway; regulation of protein import into nucleus; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	186
	11609
	ENSG00000180772
	ENSMUSG00000068122
	P50052
	P35374
	NM_000686; NM_001385624
	NM_007429
	NP_000677
	NP_031455
	Wikidata
View/Edit Human	View/Edit Mouse

Angiotensin II receptor type 2, also known as the AT₂ receptor is a protein that in humans is encoded by the AGTR2 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180772 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068122 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: AGTR2 angiotensin II receptor, type 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000180772 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068122 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: AGTR2 angiotensin II receptor, type 2".

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