Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis.[3] The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis.[4] For certain infections it is given with flucytosine.[5] It is typically given intravenously (injection into a vein).[4]
Common side effects include a reaction with fever, chills, and headaches soon after the medication is given, as well as kidney problems.[4] Allergic symptoms including anaphylaxis may occur.[4] Other serious side effects include low blood potassium and myocarditis (inflammation of the heart).[3] It appears to be relatively safe in pregnancy.[4] There is a lipid formulation that has a lower risk of side effects.[4] It is in the polyene class of medications and works in part by interfering with the cell membrane of the fungus.[3][4]
Amphotericin B was isolated from Streptomyces nodosus in 1955 at the Squibb For Medical Research Institute from cultures isolated from the streptomycete obtained from the river bed of Orinoco in that region of Venezuela[6] and came into medical use in 1958.[7][8] It is on the World Health Organization's List of Essential Medicines.[9] It is available as a generic medication.[4][10]
^"Updates to the Prescribing Medicines in Pregnancy database". Therapeutic Goods Administration (TGA). 12 May 2022. Retrieved 13 May 2022.
^"Ambisome- amphotericin b injection, powder, lyophilized, for solution". DailyMed. Retrieved 11 August 2021.
^ abcWorld Health Organization (March 2010). Control of the leishmaniasis: report of a meeting of the WHO Expert Committee on the Control of Leishmaniases. Geneva: World Health Organization. pp. 55, 88, 186. hdl:10665/44412. ISBN 9789241209496.
^ abcdefgh"Amphotericin B". The American Society of Health-System Pharmacists. Archived from the original on 2015-01-01. Retrieved January 1, 2015.
^World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 145. hdl:10665/44053. ISBN 9789241547659.
^Velázquez L (1976). Farmacología y su proyección a la clínica 13a ed (in Spanish). Oteo. p. 966. ISBN 8485152050.
^Walker SR (2012). Trends and Changes in Drug Research and Development. Springer Science & Business Media. p. 109. ISBN 9789400926592. Archived from the original on 2017-09-10.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 477. ISBN 9783527607495.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^"Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
AmphotericinB is an antifungal medication used for serious fungal infections and leishmaniasis. The fungal infections it is used to treat include mucormycosis...
the consumption of cheese contaminated with M. mucedo mould growth. AmphotericinB, a drug primarily used for treatment of patients with progressive and...
cytotoxicity. These include liposomal amphotericinB, amphotericinB lipid complex such as Abelcet (brand) amphotericinB phospholipid complex also as AmBisome...
review found that lipid formulations of amphotericinB had fewer side effects than conventional amphotericinB, though it is not clear whether there are...
including these newer drugs. In very severe cases, combination therapy with amphotericinB and an azole have been postulated, although no trials have been conducted...
concentration required in that region for therapeutic benefit. Example(s): amphotericinB. This may be used to treat some fungal infections of the vaginal region...
It may appear similar to aspergillosis. Treatment is generally with amphotericinB and surgical debridement. Preventive measures include wearing a face...
aggressive invasive aspergillosis include voriconazole and liposomal amphotericinB in combination with surgical debridement. For the less aggressive allergic...
bonds. The following polyenes are used as antimycotics for humans: amphotericinB, nystatin, candicidin, pimaricin, methyl partricin, and trichomycin...
surgery. Systemic medications used include Itraconazole, posaconazole and amphotericinB. With treatment, most people will recover, but an immunocompromised...
preparations of amphotericinB have risk of nephrotoxicity. Individuals taking amphotericinB are monitored for renal function. Liposomal amphotericinB is better...
cerebrospinal fluid, sputum, and skin biopsy. Treatment is with fluconazole or amphotericinB. Data from 2009 estimated that of the almost one million cases of cryptococcal...
usually effective. Oral or intravenous fluconazole, itraconazole, or amphotericinB may be used if these do not work. A number of topical antifungal medications...
bloodstream to peripheral organs. For invasive disease, treatments include amphotericinB, echinocandins, or extended-spectrum triazole antifungals. In the history...
Some possible medications used for visceral disease include liposomal amphotericinB, a combination of pentavalent antimonials and paromomycin, and miltefosine...
the first-line treatment for VL. Single dose amphotericinB and paromomycin/miltefosine/amphotericinB combinations were recommended by the WHO Expert...
basis of the laboratory evidence and case reports, heroic doses of amphotericinB have been the traditional mainstay of PAM treatment since the first...
cryptococcal meningitis. A new study found that brain glucose can trigger amphotericinB (AmB) tolerance of C. neoformans during meningitis which means it needs...
mild or moderate disease. In severe cases, patients are treated with amphotericinB before azole treatment. In either event, the azole treatment lasts for...
activity than colloidal formulations of amphotericinB, and demonstrated effectiveness against some amphotericinB-resistant forms of fungi. It offers an...
people with deficient immune systems. It is relatively resistant to amphotericinB, a common antifungal drug. Aspergillus terreus also produces aspterric...
this therapy. Another antimicrobial drug amphotericinB is also commonly used. Liposomal amphotericinB (L-AmB) has been a drug of choice in India, but...
the use of some antifungals against West African sleeping sickness. AmphotericinB, an antifungal drug, targets ergosterol. It binds physically to ergosterol...
2013. Some investigators have theorized that the widespread use of AmphotericinB empiric antifungal therapy selects for infections with Candida lusitaniae...
medications such as amphotericinB and nystatin, along with variable vulnerability to flucytosine and caspofungin. However, intravenous amphotericinB is a medication...
"Rabies". www.who.int. Retrieved 2023-06-16. Lindell, D. M.; Morris, S. B.; White, M. P.; Kallal, L. E.; Lundy, P. K.; Hamouda, T.; Baker, J. R.; Lukacs...
rugosa. P. kudriavzevii can be successfully treated with voriconazole, amphotericinB, and echinocandins (micafungin, caspofungin, and anidulafungin).[citation...
have similar activity to ciclosporin. Polyene antimycotics, such as amphotericinB, nystatin etc., are a subgroup of macrolides. Cruentaren is another...
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