Aminopeptidase B (EC 3.4.11.6, arylamidase II, arginine aminopeptidase, arginyl aminopeptidase, Cl—activated arginine aminopeptidase, cytosol aminopeptidase IV, L-arginine aminopeptidase) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys
This enzyme from mammalian tissues is activated by chloride ions and low concentrations of thiol compounds.
An inhibitor is bestatin (ubenimex).
^Gainer H, Russell JT, Loh YP (September 1984). "An aminopeptidase activity in bovine pituitary secretory vesicles that cleaves the N-terminal arginine from beta-lipotropin60-65". FEBS Letters. 175 (1): 135–9. doi:10.1016/0014-5793(84)80586-4. PMID 6434344.
^Belhacene N, Mari B, Rossi B, Auberger P (August 1993). "Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation". European Journal of Immunology. 23 (8): 1948–55. doi:10.1002/eji.1830230833. PMID 8344358. S2CID 855382.
^Cadel S, Pierotti AR, Foulon T, Créminon C, Barré N, Segrétain D, Cohen P (April 1995). "Aminopeptidase-B in the rat testes: isolation, functional properties and cellular localization in the seminiferous tubules". Molecular and Cellular Endocrinology. 110 (1–2): 149–60. doi:10.1016/0303-7207(95)03529-g. PMID 7672445. S2CID 6951437.
^Fukasawa KM, Fukasawa K, Kanai M, Fujii S, Harada M (November 1996). "Molecular cloning and expression of rat liver aminopeptidase B". The Journal of Biological Chemistry. 271 (48): 30731–5. doi:10.1074/jbc.271.48.30731. PMID 8940051.
^Cadel S, Foulon T, Viron A, Balogh A, Midol-Monnet S, Noël N, Cohen P (April 1997). "Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A4 hydrolase". Proceedings of the National Academy of Sciences of the United States of America. 94 (7): 2963–8. Bibcode:1997PNAS...94.2963C. doi:10.1073/pnas.94.7.2963. PMC 20305. PMID 9096329.
^Orning L, Gierse JK, Fitzpatrick FA (April 1994). "The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity". The Journal of Biological Chemistry. 269 (15): 11269–73. doi:10.1016/S0021-9258(19)78120-4. PMID 8157657.
arginyl aminopeptidase (aminopeptidaseB), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities)...
glutamyl aminopeptidase (aminopeptidase A), as well as other aminopeptidases. It does not inhibit arginyl aminopeptidase (aminopeptidaseB). Amastatin...
Membrane alanyl aminopeptidase (EC 3.4.11.2) also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N) is an enzyme that in humans is encoded...
for carboxypeptidase M. Kallidin can be converted into bradykinin by AminopeptidaseB, creating a connection between LK and the kinin-kallikrein system....
AminopeptidaseB is an enzyme that in humans is encoded by the RNPEP gene. GRCh38: Ensembl release 89: ENSG00000176393 – Ensembl, May 2017 GRCm38: Ensembl...
3390/v12010083. PMC 7019228. PMID 31936749. Tresnan, Dina B.; Holmes, Kathryn V. (1998). "Feline Aminopeptidase N is a Receptor for All Group I Coronaviruses"....
added post-translationally to proteins. Enzymes such as AminopeptidaseB and Carboxypeptidase B are able to remove arginine from a proteins N-terminus...
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C-terminal Phe, Tyr, Trp, or Leu Carboxypeptidase B - cleaves C-terminal Lys or Arg Aminopeptidase - cleaves any N-terminal amino acid Prolinase - cleaves...
Clostridial aminopeptidase (EC 3.4.11.13, Clostridium histolyticum aminopeptidase) is an enzyme. This enzyme catalyses the following chemical reaction...
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distinguishing S. pyogenes from other B-hemolytic strains by testing for the presence of pyrrolidonyl aminopeptidase. Both the Lancefield antigen grouping...
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(C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases, which cleave peptide bonds at the N-terminus of proteins. Humans,...
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