Crystal structure of bovine leucyl aminopeptidase with co-ordinated zinc ions. Rendered from PDB 1BLL.
Identifiers
Symbol
LAP
Alt. symbols
PEPS
NCBI gene
51056
HGNC
18449
OMIM
170250
RefSeq
NM_015907
UniProt
P28838
Other data
EC number
3.4.11.1
Locus
Chr. 4 p15.33
Search for
Structures
Swiss-model
Domains
InterPro
Leucyl aminopeptidases (EC 3.4.11.1, leucine aminopeptidase, LAPs, leucyl peptidase, peptidase S, cytosol aminopeptidase, cathepsin III, L-leucine aminopeptidase, leucinaminopeptidase, leucinamide aminopeptidase, FTBL proteins, proteinates FTBL, aminopeptidase II, aminopeptidase III, aminopeptidase I) are enzymes that preferentially catalyze the hydrolysis of leucine residues at the N-terminus of peptides and proteins. Other N-terminal residues can also be cleaved, however. LAPs have been found across superkingdoms. Identified LAPs include human LAP, bovine lens LAP, porcine LAP, Escherichia coli (E. coli) LAP (also known as PepA or XerB), and the solanaceous-specific acidic LAP (LAP-A) in tomato (Solanum lycopersicum).
and 19 Related for: Leucyl aminopeptidase information
Bacterial leucylaminopeptidase (EC 3.4.11.10, Aeromonas proteolytica aminopeptidase) is an enzyme. This enzyme catalyses the following chemical reaction...
Aminopeptidase III may refer to one of two enzymes: LeucylaminopeptidaseAminopeptidase I This disambiguation page lists articles associated with the...
R (July 1990). "Prolyl aminopeptidase from rat brain and kidney. Action on peptides and identification as leucylaminopeptidase". European Journal of Biochemistry...
2000). "Salmonella enterica serovar typhimurium peptidase B is a leucylaminopeptidase with specificity for acidic amino acids". Journal of Bacteriology...
Erepsin may contain dipeptidases, aminopeptidases, occasionally carboxypeptidases, and these include leucylaminopeptidase, prolinase, prolidase and others...
enzymes such as alkaline phosphatase, γ-glutamyltransferase, and leucylaminopeptidase. In addition, orellanine has also been shown to interfere with the...
neuropeptide, oxytocin. The most well-characterized oxytocinase is leucyl/cystinyl aminopeptidase, which is also an enkephalinase. Other oxytocinases are also...
and designing reservoirs Insulin responsive aminopeptidase, an alias for Leucyl/cystinyl aminopeptidase This disambiguation page lists articles associated...
indels were identified for this genus in the following proteins: leucylaminopeptidase, helicase-exonuclease AddAB subunit AddA, class I SAM-dependent...
C. Oxytocin is known to be metabolized by the oxytocinase, leucyl/cystinyl aminopeptidase. Other oxytocinases are also known to exist. Amastatin, bestatin...
a number of tissue homogenates from Periplaneta americana a soluble aminopeptidase as a key enzyme that degrades proctolin was identified. Another enzyme...
endogenous the enkephalin peptides. It does so by inhibiting the enzymes aminopeptidase N (APN), dipeptidyl peptidase III (DPP3), angiotensin-converting enzyme...
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