Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an M1 zinc aminopeptidase [Uniprot, A0A0A7E6D4] involved in the antigen processing and presentation pathway. ERAP1 is mainly located in the endoplasmic reticulum (ER), where it trims peptides at their N-terminus, adapting them for presentation by MHC class I molecules (MHC-I).[1]
antigen processing and presentation of peptide antigen via MHC class I
proteolysis
positive regulation of angiogenesis
membrane protein ectodomain proteolysis
angiogenesis
fat cell differentiation
peptide catabolic process
antigen processing and presentation of endogenous peptide antigen via MHC class I
regulation of blood pressure
signal transduction
cell-cell signaling
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
51752
80898
Ensembl
ENSG00000164307
ENSMUSG00000021583
UniProt
Q9NZ08
Q9EQH2
RefSeq (mRNA)
NM_001040458 NM_001198541 NM_016442 NM_001349244
NM_030711
RefSeq (protein)
NP_001035548 NP_001185470 NP_057526 NP_001336173
NP_109636
Location (UCSC)
Chr 5: 96.76 – 96.81 Mb
Chr 13: 74.79 – 74.84 Mb
PubMed search
[4]
[5]
Wikidata
View/Edit Human
View/Edit Mouse
^Shastri N, Nagarajan N, Lind KC, Kanaseki T (February 2014). "Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum". Current Opinion in Immunology. 26: 123–127. doi:10.1016/j.coi.2013.11.006. ISSN 0952-7915. PMC 3932006. PMID 24556408.
^ abcGRCh38: Ensembl release 89: ENSG00000164307 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021583 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
aminopeptidase 1 (ERAP1) is an M1 zinc aminopeptidase [Uniprot, A0A0A7E6D4] involved in the antigen processing and presentation pathway. ERAP1 is mainly located...
2011). "Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming". Proceedings...
Estrada Endoplasmic reticulum aminopeptidase protein, a class of enzymes ERAP1 ERAP2 This disambiguation page lists articles associated with the title...
JJ, Su Z, Harvey D, Kochan G, et al. (July 2011). "Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the...
Dihydropyrimidinase-like protein 3 EGR1: early growth response protein 1 ERAP1: endoplasmic reticulum aminopeptidase 1 (previously called ARTS-1) ERAP2:...
patients. ERAP2 is an aminopeptidase that, together with the closely related ERAP1, trims peptides in the endoplasmic reticulum and loads these peptides on...
humans involved in antigen presentation. It is encoded by the ERAP2 gene. ERAP1 and ERAP2 are Aminopeptidases, able to trim precursors to antigenic peptides...
Gabriele; van Endert, Peter M. (2005). "Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum". Nature...
JJ, Su Z, Harvey D, Kochan G, et al. (August 2011). "Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the...
Wordsworth BP, Brown MA, Donnelly P (July 2011). "Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the...
Global Information
