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Aminocaproic acid
Skeletal formula
Ball-and-stick model of the zwitterionic form of the molecule found in the crystal structure[1][2]
Aminocaproic acid (also known as ε-aminocaproic acid, ε-Ahx, or 6-aminohexanoic acid) is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue. Such enzymes include proteolytic enzymes like plasmin, the enzyme responsible for fibrinolysis. For this reason it is effective in treatment of certain bleeding disorders, and it is sold under the brand name Amicar.[3] Aminocaproic acid is also an intermediate in the polymerization of Nylon-6, where it is formed by ring-opening hydrolysis of caprolactam. The crystal structure determination showed that the 6-aminohexanoic acid is present as a salt, at least in the solid state.[4]
^G. J. Reiss (2010). "CSD Communication AMCAPR11: 6-Aminohexanoic acid". Cambridge Structural Database: Access Structures. Cambridge Crystallographic Data Centre. doi:10.5517/ccv38nv. Retrieved 18 August 2021.
^Bodor G, Bednowitz AL, Post B (1967). "The crystal structure of ε-aminocaproic acid". Acta Crystallographica. 23 (3): 482–490. doi:10.1107/S0365110X67003019.
^ ab"Amicar- aminocaproic acid solution Amicar- aminocaproic acid tablet". DailyMed. 9 October 2020. Retrieved 11 November 2020.
^Reiss GJ (2011), "Crystal Structure", CCDC 777717: Experimental Crystal Structure Determination, Cambridge Crystallographic Data Centre, doi:10.5517/ccv38nv, retrieved 24 October 2019
Aminocaproicacid (also known as ε-aminocaproicacid, ε-Ahx, or 6-aminohexanoic acid) is a derivative and analogue of the amino acid lysine, which makes...
inhibitors of fibrinolysis. Examples include aminocaproicacid (ε-aminocaproicacid) and tranexamic acid. These lysine-like drugs interfere with the formation...
Tranexamic acid has roughly eight times the antifibrinolytic activity of an older analogue, ε-aminocaproicacid.[citation needed] Tranexamic acid also directly...
described in the late 1800s when it was prepared by the cyclization of ε-aminocaproicacid, the product of the hydrolysis of caprolactam. World demand for caprolactam...
breakdown in the clot. Antifibrinolytics, such as aminocaproicacid (ε-aminocaproicacid) and tranexamic acid are used as inhibitors of fibrinolysis. Their...
to give a peptide containing the 6-hydroxynorleucine (6-hydroxy-2-aminocaproicacid) residue, which (unlike allysine) is stable to proteolysis. Luna C...
that, compared to other antifibrinolytic drugs (epsilon-aminocaproicacid and tranexamic acid) aprotinin may increase the risk of death. On October 29...
leupeptin, aprotinin, pepstatin, 1-5 mM EDTA, 0.5-1 mM EGTA, 5 mM aminocaproicacid) or commercial protease inhibitor cocktail (use according to the manufacturer's...
First-line options include the antifibrinolytics tranexamic acid or aminocaproicacid. Estrogens can be used to stop bleeding from angiodysplasia. Estrogens...
nonhistaminergic angioedema, antifibrinolytics such as tranexamic acid or ε-aminocaproicacid may be effective. Cinnarizine may also be useful because it blocks...
and may be treated with an antifibrinolytic, such as tranexamic acid or aminocaproicacid, in the appropriate clinical setting. A single, modified TEG assay...
activator (tPA). Overdose of streptokinase or tPA can be treated with aminocaproicacid. Any prior intracranial hemorrhage Known structural cerebral vascular...
Nakamura, Reid K. (2016-09-26). "Use of Yunnan Baiyao and epsilon aminocaproicacid in dogs with right atrial masses and pericardial effusion". Journal...
increasingly popular in the treatment of major bleeding. Tranexamic acid and aminocaproicacid inhibit fibrinolysis and lead to a de facto reduced bleeding rate...
"A mechanism for hereditary angioedema caused by a lysine 311-to-glutamic acid substitution in plasminogen". Blood. 139 (18): 2816–2829. doi:10.1182/blood...
Haemophilus infections can be prevented via immunization. Epsilon-aminocaproicacid could be used to treat hereditary C1-INH deficiency, though the possible...
had been made from ε-aminocaproicacid was due to cyclization reactions, so he replaced ε-aminocaproicacid with 9-aminononoic acid which would not cyclize...
with an Amagami Sister as Yae Amagami Eyedrops (2016) as Epsilon-AminocaproicAcid Cute Executive Officer (2021–2023) as Yuki Karuizawa Ganbare Dōki-chan...
airline American History X, a 1998 film Aminohexanoic acid (Ahx), also known as Aminocaproicacid Renault AHx, a range of light/medium trucks Vehicle registration...
may be used in those with mild haemophilia A. Tranexamic acid or epsilon aminocaproicacid may be given along with clotting factors to prevent breakdown...
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