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Amide reduction information


Amide reduction is a reaction in organic synthesis where an amide is reduced to either an amine or an aldehyde functional group.[1][2]

  1. ^ Nishimura, Shigeo (2001). Handbook of Heterogeneous Catalytic Hydrogenation for Organic Synthesis (1st ed.). New York: Wiley-Interscience. pp. 406–411. ISBN 9780471396987.
  2. ^ March, Jerry (1985), Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 3rd edition, New York: Wiley, ISBN 9780471854722, OCLC 642506595

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Amide reduction

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Amide reduction is a reaction in organic synthesis where an amide is reduced to either an amine or an aldehyde functional group. Catalytic hydrogenation...

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Amide

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In organic chemistry, an amide, also known as an organic amide or a carboxamide, is a compound with the general formula R−C(=O)−NR′R″, where R, R', and...

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Organic redox reaction

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compounds Carbonyl reduction Amide reduction Nitrile reduction Reduction of nitro compounds Reduction of imines and Schiff bases Reduction of aromatic compounds...

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Aldehyde

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1016/S0040-4039(00)88578-0. Weerman, R.A. (1913). "Einwirkung von Natriumhypochlorit auf Amide ungesättigter Säuren". Justus Liebigs Annalen der Chemie. 401 (1): 1–20...

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Nicotinamide

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B family of medications, specifically the vitamin B3 complex. It is an amide of nicotinic acid. Foods that contain niacinamide include yeast, meat, milk...

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Weinreb ketone synthesis

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reported the synthesis of aldehydes by reduction of the amide with an excess of lithium aluminum hydride (see amide reduction). The major advantage of this method...

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Stephen aldehyde synthesis

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salt is obtained from reaction of an amide PhCONHPh with phosphorus pentachloride. Amide reduction Nitrile reduction Pinner reaction – a similar reaction...

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Mescaline

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reductive amination. Ester reduction of Eudesmic acid's methyl ester followed by halogenation, Kolbe nitrile synthesis, and nitrile reduction. Amide reduction...

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Lithium aluminium hydride

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(see: carbonyl reduction). Similarly, it converts amide, nitro, nitrile, imine, oxime, and organic azides into the amines (see: amide reduction). It reduces...

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Ergine

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Ergine, also known as d-lysergic acid amide (LSA) and d-lysergamide, is an ergoline alkaloid that occurs in various species of vines of the Convolvulaceae...

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Carbonyl reduction

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forming a thioester or a Weinreb amide, then reducing the new species to an aldehyde through the Fukuyama reduction or Weinreb reaction respectively,...

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Copper chromite

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requires the chemist to use a higher ratio of catalyst to reagents. Amide reduction Elements, American. "Copper Chromite". American Elements. Retrieved...

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Amine

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substituted-ammonium carboxylate salt → dehydration heat N | R 2 R 1 | − C O ‖ − R 3 ⏟ amide + H 2 O ⏟ water {\displaystyle {\underbrace {\ce {H-\!\!{\overset {\displaystyle...

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Urea

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formula CO(NH2)2. This amide has two amino groups (–NH2) joined by a carbonyl functional group (–C(=O)–). It is thus the simplest amide of carbamic acid. Urea...

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Theanine

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and its primary amide, L-glutamine (also a proteinogenic amino acid). Theanine is a derivative of glutamine that is ethylated on the amide nitrogen (as the...

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Acetamide

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methyl (CH3) groups either side of the carbonyl (CO), and urea which has two amide (NH2) groups in those locations. Acetamide is also a naturally occurring...

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Rhenium trioxide

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Rhenium trioxide finds some use in organic synthesis as a catalyst for amide reduction. H. Nechamkin, C. F. Hiskey, "Rhenium(VI): Oxide (Rhenium Trioxide)"...

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Oxime

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primary amines. In general, oximes can be changed to the corresponding amide derivatives by treatment with various acids. This reaction is called Beckmann...

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Acetanilide

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in place of 'amide' in systematic or retained names of amides. (…) However, names expressing N-substitution by a phenyl group on an amide are preferred...

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Anesthetic

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suffix "–caine" in their names. Local anesthetics can be either ester- or amide-based. Ester local anesthetics are generally unstable in solution and fast-acting...

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Carboxylic acid

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group tends to dimerise to form oxalic acid. Acid anhydride Acid chloride Amide Amino acid Ester List of carboxylic acids Dicarboxylic acid Pseudoacid Thiocarboxy...

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Anandamide

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from the Sanskrit word ananda, which means "joy, bliss, delight", plus amide. Anandamide is derived from the non-oxidative metabolism of arachidonic...

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Lidocaine

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the brand name Xylocaine among others, is a local anesthetic of the amino amide type. It is also used to treat ventricular tachycardia. When used for local...

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Bupivacaine

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may also increase the length of labor. It is a local anaesthetic of the amide group. Bupivacaine was discovered in 1957. It is on the World Health Organization's...

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Nitrile

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a related dehydration, secondary amides give nitriles by the von Braun amide degradation. In this case, one C-N bond is cleaved. The conversion of aldehydes...

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Acmella oleracea

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(2E,6Z,8E)-deca-2,6,8-trienoic acid isobutyl amide (2E,7Z,9E)-Undeca-2,7,9-trienoic acid isobutyl amide, another alkylamide from Acmella oleracea (2E)-Undeca-2-en-8...

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