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Bromhexine information


Bromhexine
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • A (Aus)
ATC code
  • R05CB02 (WHO)
Legal status
Legal status
  • In general: Over-the-counter (OTC)
Pharmacokinetic data
Bioavailability75–80%
MetabolismExtensive hepatic
MetabolitesAmbroxol, others
Elimination half-life12 hr
ExcretionUrine
Identifiers
IUPAC name
  • 2,4-Dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline
CAS Number
  • 3572-43-8 checkY
PubChem CID
  • 2442
DrugBank
  • DB09019 ☒N
ChemSpider
  • 2348 checkY
UNII
  • Q1J152VB1P
KEGG
  • D07542 checkY
ChEBI
  • CHEBI:77032 ☒N
ChEMBL
  • ChEMBL253376 checkY
CompTox Dashboard (EPA)
  • DTXSID6022686 Edit this at Wikidata
ECHA InfoCard100.020.622 Edit this at Wikidata
Chemical and physical data
FormulaC14H20Br2N2
Molar mass376.136 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • Brc1cc(c(N)c(Br)c1)CN(C)C2CCCCC2
InChI
  • InChI=1S/C14H20Br2N2/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17/h7-8,12H,2-6,9,17H2,1H3 checkY
  • Key:OJGDCBLYJGHCIH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Bromhexine is a mucolytic drug used in the treatment of respiratory disorders associated with viscid or excessive mucus.[1] It was developed in the research laboratory of Boehringer Ingelheim in the late 1950s as an active ingredient for pharmaceutical use, patented in 1961, introduced in 1963 under the trademark of Bisolvon® and came into medical use in 1966.[2]

  1. ^ Morton I, Hall J (1999). Concise Dictionary of Pharmacological Agents. Springer. p. 55. ISBN 0-7514-0499-3. Retrieved 2009-06-03.
  2. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 544. ISBN 9783527607495.

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Bromhexine

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Bromhexine is a mucolytic drug used in the treatment of respiratory disorders associated with viscid or excessive mucus. It was developed in the research...

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Ambroxol

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in Gaucher and Parkinson's disease. Both ambroxol and its parent drug bromhexine have been shown to induce autophagy in several cell types, and ambroxol...

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Justicia adhatoda

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yield of the herbage has been measured as 0.541 to 1.1% by dry weight. Bromhexine, a serine protease inhibitor with mucolytic properties available over-the-counter...

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Mucoactive agent

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591 Mucoactive drugs include: acetylcysteine ambroxol ammonium chloride bromhexine carbocisteine dornase alfa erdosteine guaifenesin mecysteine potassium...

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Mollipect

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name for a medication whose active substances are: Bromhexine, a mucolytic agent. In addition, bromhexine has antioxidant properties. Ephedrine, a sympathomimetic...

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Benadryl

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and chest congestion. The main ingredients found are guaifenesin and bromhexine hydrochloride. It is to be taken orally to provide relief from cough and...

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Vasicine

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the alkaloids. Vasicine is reported to have a uterine stimulant effect. Bromhexine, a synthetic compound imitating the molecular shape of vasicine[citation...

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Schedule H

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ACETIC ACID 64. BITOSCANATE 65. BLEOMYCIN 66. PRIMONIDINE TARTRATE 67. BROMHEXINE HYDROCLORIDE 68. BROMOCRIPTINE MESYLATE 69. BUDESONIDE 70. BULAQUINE 71...

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ATC code R05

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Hederae helicis folium R05CA13 Cineole R05CB01 Acetylcysteine R05CB02 Bromhexine R05CB03 Carbocisteine R05CB04 Eprazinone R05CB05 Mesna R05CB06 Ambroxol...

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Boehringer Ingelheim

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Health Care (sold to Sanofi): Antistax (red vine leaf extract) Bisolvon (bromhexine) Buscopan / Buscapina (hyoscine butylbromide) Dulcolax (bisacodyl) Zantac...

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Cold medicine

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lungs, bronchi, and trachea. Examples are carbocisteine, ambroxol, and bromhexine. Expectorants are substances claimed to make coughing easier while enhancing...

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Fluvoxamine

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Chanpiwat K, et al. (April 2024). "Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in...

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Controversies involving Jair Bolsonaro

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drugs such as chloroquine, hydroxychloroquine, ivermectin, azithromycin, bromhexine, nitazoxanide, anticoagulants and zinc supplements. In March 2020, chloroquine...

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Grindeks

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Zopiclone Bisacodyl Digoxin Meldonium Phosphate (Mildronate®) Rivaroxaban Bromhexine Dimetindene Memantine hydrochloride Sitagliptin Bupivacaine hydrochloride...

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TMPRSS2

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is the over-the-counter (in most countries) mucolytic cough medicine bromhexine, which is also being investigated as a possible treatment for COVID-19...

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List of compounds with carbon number 14

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C14H19O6P crotoxyphos 7700-17-6 C14H20 diadamantane 2292-79-7 C14H20Br2N2 bromhexine 3572-43-8 C14H20ClNO2 acetochlor 34256-82-1 C14H20ClNO2 alachlor 15972-60-8...

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