For other uses, see Alcohol dehydrogenase (disambiguation).
Alcohol dehydrogenase
Crystallographic structure of the homodimer of human ADH5.[1]
Identifiers
EC no.
1.1.1.1
CAS no.
9031-72-5
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Alcohol dehydrogenases (ADH) (EC 1.1.1.1) are a group of dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of nicotinamide adenine dinucleotide (NAD+) to NADH. In humans and many other animals, they serve to break down alcohols that are otherwise toxic, and they also participate in the generation of useful aldehyde, ketone, or alcohol groups during the biosynthesis of various metabolites. In yeast, plants, and many bacteria, some alcohol dehydrogenases catalyze the opposite reaction as part of fermentation to ensure a constant supply of NAD+.
Alcoholdehydrogenases (ADH) (EC 1.1.1.1) are a group of dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between...
will typically have a higher alcohol tolerance. The alcohol tolerance is also connected with activity of alcoholdehydrogenases (a group of enzymes responsible...
extract inhibited aldehyde dehydrogenase activity, lending credence to an Asian folklore warning against consuming durian with alcohol. H − C | H H | − C |...
Alcohol intolerance is due to a genetic polymorphism of the aldehyde dehydrogenase enzyme, which is responsible for the metabolism of acetaldehyde (produced...
in some cases this has physiological significance: for example, alcoholdehydrogenase catalyzes the oxidation of ethanol to acetaldehyde in animals, but...
metabolic byproduct of the catabolic metabolism of alcohol, and is caused by an aldehyde dehydrogenase 2 deficiency. This syndrome has been associated with...
oxidation of ethanol by the liver enzyme alcoholdehydrogenase and is a contributing cause of hangover after alcohol consumption. Pathways of exposure include...
into the bloodstream. The lower gastrointestinal tract lacks the alcoholdehydrogenase enzyme present in the stomach and liver that breaks down ethanol...
Alcoholdehydrogenase 1B is an enzyme that in humans is encoded by the ADH1B gene. The protein encoded by this gene is a member of the alcohol dehydrogenase...
strain. Pyrococcus furiosus possesses several highly thermostable alcoholdehydrogenases (ADHs): the short-chain AdhA, the iron-containing AdhB, the zinc-containing...
initiated by the enzyme alcoholdehydrogenase in the liver. Methanol is converted to formaldehyde via alcoholdehydrogenase and formaldehyde is converted...
cerevisiae. Aryl-alcoholdehydrogenase uses an aromatic alcohol and NAD+ to produce an aromatic aldehyde, NADH and H+. Aryl-alcoholdehydrogenase (NADP+) uses...
to the aldehyde dehydrogenase family of enzymes. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. ALDH2...
Blood alcohol content (BAC), also called blood alcohol concentration or blood alcohol level, is a measurement of alcohol intoxication used for legal or...
without acidosis." Isopropyl alcohol is oxidized to form acetone by alcoholdehydrogenase in the liver and has a biological half-life in humans between 2...
CH3CHO + NADH + H+ → C2H5OH + NAD+ This reaction is catalyzed by alcoholdehydrogenase (ADH1 in baker's yeast). As shown by the reaction equation, glycolysis...
metabolites. Fomepizole is a competitive inhibitor of the enzyme alcoholdehydrogenase, found in the liver. This enzyme plays a key role in the metabolism...
dehydrogenated to acetaldehyde by alcoholdehydrogenase, and further into acetyl CoA by acetaldehyde dehydrogenase. During this reaction 2 NADH are produced...
literature refers to retinol dehydrogenase as an enzyme that oxidizes retinol in general, such as class IV alcoholdehydrogenase (ADH4), which reportedly...
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