Foot-and-mouth disease - acantholysis in a sample of a skin vesicle: Necrosis of the stratum spinosum can be observed, and keratinocytes floating in the vesicular fluid (spongiosa).
Specialty
Dermatology
Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes,[1] seen in diseases such as pemphigus vulgaris.[2] It is absent in bullous pemphigoid, making it useful for differential diagnosis.
This histological feature is also seen in herpes simplex infections (HSV 1 and 2) and varicella zoster infections (chicken pox and shingles).
^Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. Page 1230. ISBN 0-7216-0187-1.
^"Acantholysis - Medical Definition from MediLexicon". medilexicon.com. Archived from the original on 2016-07-31. Retrieved 2017-04-22.
Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, seen in diseases such as...
from each other and the epidermis becomes detached, a phenomenon called acantholysis. This causes blisters that slough off and turn into sores. In some cases...
pruritic, papulovesicular dermatosis characterized histologically by acantholysis: 529 with or without dyskeratosis. Once confirmed, most cases of Grover's...
the clinical picture resembles a blister. These blisters are due to acantholysis, or breaking apart of intercellular connections through an autoantibody-mediated...
McGraw-Hill Medical. p. 427. ISBN 9780071632447. Seshadri, Divya (2013). "Acantholysis revisited: Back to basics". Indian J Dermatol Venereol Leprol. 79 (1):...
histologically by intraepidermal bullae with neutrophils, some eosinophils, and acantholysis.: 465 Early descriptions were made by Darrell Wilkinson, a British dermatologist...
Dsg3 (Desmoglein 3) and sometimes Dsg1. PV is manifested by suprabasal acantholysis, or blisters in the mucous membrane and blisters in the epidermis. PF...
cells together. The process leads to the loss of cellular connections (acantholysis), and ultimately results in blistering of the skin. Lesions heal without...
formed into a desmosome. This in turn causes a loss of adhesion with acantholysis as a result. The National Institute of Arthritis and Musculoskeletal...
to pemphigus, however unlike pemphigus, pemphigoid does not feature acantholysis, a loss of connections between skin cells. Pemphigoid is more common...
results from the disruption of tonofilaments in the desmosomes with acantholysis and intra-epidermal blister formation. "Just the facts…Paederus Beetles"...
a specific immunoprecipitation pattern Minor: Histologic evidence of acantholysis (loss of intercellular connections leading to breaking apart of the skin;...
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