Since antiretroviral therapy requires a lifelong treatment regimen, research to find more permanent cures for HIV infection is currently underway.[1] It is possible to synthesize zinc finger nucleotides with zinc finger components that selectively (almost selectively) bind to specific portions of DNA. Conceptually, targeting and editing could focus on host cellular co-receptors for HIV or on proviral HIV DNA.
^Deeks, S. G.; McCune, J. M. (2010). "Can HIV be cured with stem cell therapy?". Nature Biotechnology. 28 (8): 807–810. doi:10.1038/nbt0810-807. PMID 20697404. S2CID 20312608.
and 24 Related for: Zinc finger nuclease treatment of HIV information
lifelong treatment regimen, research to find more permanent cures for HIV infection is currently underway. It is possible to synthesize zincfinger nucleotides...
Zincfingernucleases that disrupt the CCR5 gene in CD4+ human T-cells as a potential treatment for HIV/AIDS. The majority of engineered zincfinger arrays...
engineered nucleases, i.e. all three major classes of these enzymes—zincfingernucleases (ZFNs), transcription activator-like effector nucleases (TALENs)...
(M) or a nuclease (N). Modification of the endogenous DNA-binding zincfinger domain is the basis of the most advanced field in construction of gene-specific...
zincfingernucleases. Since 2009 more accurate and easier systems to implement have been developed. Transcription activator-like effector nucleases (TALENs)...
Genetically Modified at the CCR5 Gene by ZincFingerNucleases SB-728 for HIV (Zinc-Finger)". U.S. National Institutes of Health. 9 December 2009. Retrieved...
Alongside zincfingernucleases and transcription activator-like effector nuclease (TALEN) proteins, Cas9 is becoming a prominent tool in the field of genome...
effector nucleases (TALENs) provided an easier way to target a double-stranded break to a specific location on the DNA strand. Both zincfingernucleases and...
likelihood of oncogenesis and using zinc-fingernucleases to further target gene insertion. No leukemia cases have yet been seen in trials of ADA-SCID,...
from monolaurin, L-lysine, aspirin, lemon balm, topical zinc, or licorice root cream in treatment, these preliminary studies have not been confirmed by...
expression. Zinc-finger nucleases (ZFNs) are enzymes generated by fusing a zincfinger DNA-binding domain to a DNA-cleavage domain. Zincfinger recognizes between...
processes of homologous recombination and nonhomologous end-joining. There are four families of engineered nucleases: meganucleases, zincfingernucleases, transcription...
HSV-2 increases the risk of acquiring HIV. HSV has been a model virus for many studies in molecular biology. For instance, one of the first functional promoters...
engineered nucleases that create breaks at specific points. There are four families of engineered nucleases: meganucleases, zincfingernucleases, transcription...
engineered nucleases that create breaks at specific points. There are four families of engineered nucleases: meganucleases, zincfingernucleases, transcription...
by utilizing zincfingernucleases or by including certain sequences such as the beta-globin locus control region to direct the site of integration to...
Bias in Ecological Analysis: a Case Study for Quantitative Taq Nuclease Assays in Analyses of Microbial Communities". Applied and Environmental Microbiology...
associated site-specific activity of the sTF (usually transcriptional regulation). They further used the zincfingers as components of complex-forming sTFs, which...
N (February 2005). "Recruitment of mRNA-destabilizing protein TIS11 to stress granules is mediated by its zincfinger domain". Experimental Cell Research...
Study of Genome Editing by the ZincFingerNuclease (ZFN) Therapeutic SB-913 in Subjects With MPS II". ClinicalTrials.gov. U.S. National Library of Medicine...
zincfingernuclease as well as endonuclease to prevent HSV from replicating. Most recently Jerome and his lab were able to demonstrate cleavage of latent...
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