positive regulation of phosphatidylinositol biosynthetic process
positive regulation of antral ovarian follicle growth
positive regulation of interferon-gamma production
blastocyst formation
positive regulation of interleukin-4 production
oocyte development
positive regulation of type IV hypersensitivity
positive regulation of transcription, DNA-templated
humoral immune response mediated by circulating immunoglobulin
positive regulation of acrosome reaction
positive regulation of humoral immune response
positive regulation of T cell proliferation
binding of sperm to zona pellucida
negative regulation of binding of sperm to zona pellucida
positive regulation of ovarian follicle development
positive regulation of acrosomal vesicle exocytosis
negative regulation of transcription, DNA-templated
phosphatidylinositol-mediated signaling
single fertilization
egg coat formation
regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7784
22788
Ensembl
ENSG00000188372
ENSMUSG00000004948
UniProt
P21754
P10761
RefSeq (mRNA)
NM_007155 NM_001110354
NM_011776
RefSeq (protein)
NP_001103824 NP_009086
NP_035906
Location (UCSC)
Chr 7: 76.4 – 76.44 Mb
Chr 5: 136.01 – 136.02 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Zona pellucida sperm-binding protein 3, also known as zona pellucida glycoprotein 3 (Zp-3) or the sperm receptor, is a ZP module-containing protein that in humans is encoded by the ZP3 gene.[5] ZP3 is the glycoprotein in the zona pellucida most important for inducting the acrosome reaction of sperm cells at the beginning of fertilization.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000188372 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000004948 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: zona pellucida glycoprotein 3 (sperm receptor)".
^Litscher, E. S.; Williams, Z.; Wassarman, P. M. (2009). "Zona pellucida glycoprotein ZP3 and fertilization in mammals". Molecular Reproduction and Development. 76 (10): 933–941. doi:10.1002/mrd.21046. PMID 19504560. S2CID 21186053.
is a ZP module-containing protein that in humans is encoded by the ZP3 gene. ZP3 is the glycoprotein in the zona pellucida most important for inducting...
needed] In the mouse: ZP3 allows species-specific sperm binding ZP2 mediates subsequent sperm binding ZP1 cross-links ZP2 and ZP3. In humans, five days...
ionophores in vitro, progesterone released by nearby cumulus cells and binding to ZP3 of the zona pellucida. The cumulus cells are embedded in a gel-like substance...
N-acetylglucosamine residues on the ZP3 and is important for binding with the sperm and activating the acrosome reaction. ZP3 is sufficient though unnecessary...
sperm-binding protein 1 is a protein that cross-links ZP2 and ZP3. Aberrant ZP1 results in sequestration of ZP3 in the cytoplasm, thereby preventing the formation...
the zona pellucida, which is an extracellular matrix of glycoproteins. A ZP3 glycoprotein on the zona pellucida binds to a receptor on the cell surface...
the head sink into the egg. In the mouse, it has been demonstrated that ZP3, one of the proteins that make up the zona pellucida, binds to a partner...
enzymes released by the granules cause the zona reaction, which removes the ZP3 ligands from the zona pellucida. Clinically, the perivitelline space is relevant...
released by cortical granules digest sperm receptor glycoproteins ZP2 and ZP3 so that they can no longer bind spermatozoon. Acrosome reaction - The analogous...
"Nicarbazin reduces egg production and fertility in White Pekin ducks via reducing ZP3 in the perivitelline membrane". Poultry Science. 86 (Suppl. 1): 536. Avery...
injection causes a treated female mammal to produce antibodies that bind to ZP3 on the surface of her ovum, blocking sperm from fertilizing it for periods...
showed that is shares the same ZP-N fold first identified in structures of ZP3 (PDB: 3D4C, 3D4G, 3EF7, 3NK3, 3NK4). This provided experimental evidence...
ionophores in vitro, progesterone released by nearby cumulus cells and binding to ZP3 of the zona pellucida. The initial change is called "hyperactivation", which...
in acrosome reaction. ZP3 is a glycoprotein present in zona pelucida and it interacts with receptors in spermatozoon. So, ZP3 can activate G protein...
Bork P, Sander C (1992). "A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor". FEBS Lett. 300 (3): 237–40. Bibcode:1992FEBSL...
equivalent to the cortical reaction in sea urchins. The terminal sugars from ZP3 are cleaved to release the sperm and prevent new binding. The meiotic cycle...
Kipersztok S, Osawa GA, Liang LF, et al. (1995). "POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue". Genomics. 25 (2): 354–9....
zona pellucida. FIGLA is related to the zona pellucida genes ZP1, ZP2, and ZP3. Mutation in the FIGLA gene are associated with premature ovarian failure...
growing mouse oocytes microinjected with epitope-tagged cDNAs for mZP2 and mZP3". Molecular Biology of the Cell. 13 (2): 530–41. doi:10.1091/mbc.01-09-0440...
action of nicarbazin is related to the inhibition of sperm receptor sites ZP3. These effects on egg production and weight have proven to be reversible...
– via YouTube. Brat (6 September 2018). v=R7vh7tX2wr8&t=22s&list=PLVewHiZp3_LPaLotMbsCTH1Pij4WnhmOZ&index=2 "TOTAL ECLIPSE - Season 2 - Ep. 1: "Thangs""...
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