CNOT6L information

CNOT6L
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3NGN, 3NGO, 3NGQ, 5DV2
Identifiers
Aliases	CNOT6L, CCR4b, CCR4-NOT transcription complex subunit 6 like
External IDs	OMIM: 618069; MGI: 2443154; HomoloGene: 100830; GeneCards: CNOT6L; OMA:CNOT6L - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	77,819,615 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	96,312,030 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; mucosa of ileum; ; superficial temporal artery; ; tibialis anterior muscle; ; bone marrow cells; ; thymus; ; corpus epididymis; ; tonsil; ; jejunal mucosa; ; epithelium of colon;
	Top expressed in
	hair follicle; ; skin of external ear; ; Rostral migratory stream; ; secondary oocyte; ; primary oocyte; ; vas deferens; ; utricle; ; efferent ductule; ; blood; ; tibiofemoral joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	poly(A)-specific ribonuclease activity; metal ion binding; protein binding; nuclease activity; exonuclease activity; hydrolase activity; 3'-5'-exoribonuclease activity;
Cellular component	cytoplasm; CCR4-NOT complex; nucleus; cytosol;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; regulation of transcription, DNA-templated; RNA phosphodiester bond hydrolysis, exonucleolytic; mRNA processing; transcription, DNA-templated; positive regulation of cytoplasmic mRNA processing body assembly; mRNA destabilization; positive regulation of cell population proliferation; gene silencing; regulation of translation; nucleic acid phosphodiester bond hydrolysis; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
	Sources:Amigo / QuickGO
Orthologs
	246175
	231464
	ENSG00000138767
	ENSMUSG00000034724
	Q96LI5
	Q8VEG6
	NM_001286790; NM_144571; NM_001365006; NM_001365007
	NM_001285511; NM_001285514; NM_144910; NM_178854
	NP_001273719; NP_653172; NP_001351935; NP_001351936
	NP_001272440; NP_001272443; NP_659159; NP_849185
	Wikidata
View/Edit Human	View/Edit Mouse

CCR4-NOT transcription complex subunit 6 like is a protein that in humans is encoded by the CNOT6L gene.^[5] It is a paralog of CNOT6 and therefore a potential subunit of the CCR4-Not deadenylase complex.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138767 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034724 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CCR4-NOT transcription complex subunit 6 like". Retrieved 2020-04-15.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138767 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034724 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CCR4-NOT transcription complex subunit 6 like". Retrieved 2020-04-15.

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