Yellow nail syndrome: This patient has a 20-year history of severe lymphedema of her legs; thick, ridged, yellowish, hypercurved thumbnails (top right); similarly affected, yellow-green to brown toenails (bottom right); and bilateral, chylous pleural effusions. A sample of her chylous pleural fluid is shown to the left of the radiograph.
Specialty
Dermatology
Yellow nail syndrome, also known as "primary lymphedema associated with yellow nails and pleural effusion",[1]: 849 is a very rare medical syndrome that includes pleural effusions, lymphedema (due to under development of the lymphatic vessels) and yellow dystrophic nails.[2] Approximately 40% will also have bronchiectasis. It is also associated with chronic sinusitis and persistent coughing. It usually affects adults.[3][4]: 665 [5]
^James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
^"Yellow nail syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 2018-04-17.
^"Yellow nail syndrome. DermNet NZ". Archived from the original on 2013-11-15. Retrieved 2008-03-19.
^Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
^Maldonado, Fabien; Ryu, Jay H (July 2009). "Yellow nail syndrome". Current Opinion in Pulmonary Medicine. 15 (4): 371–375. doi:10.1097/MCP.0b013e32832ad45a. PMID 19373089. S2CID 24728854.
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