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White pulp information


White pulp
Spleen
Transverse section of a portion of the spleen. (Lymphatic nodule labeled at center right.)
Details
Precursormesoderm
Arterytrabecular artery
Veintrabecular vein
Identifiers
Latinnoduli lymphoidei splenici
TA98A13.2.01.006
TA25176
FMA62805
Anatomical terminology
[edit on Wikidata]

White pulp is a histological designation for regions of the spleen (named because it appears whiter than the surrounding red pulp on cross section), that encompasses approximately 25% of splenic tissue. White pulp consists entirely of lymphoid tissue.

Specifically, the white pulp encompasses several areas with distinct functions:

  • The periarteriolar lymphoid sheaths (PALS) are typically associated with the arteriole supply of the spleen; they contain T lymphocytes.
  • Lymph follicles with dividing B lymphocytes are located between the PALS and the marginal zone bordering on the red pulp. IgM and IgG2 are produced in this zone. These molecules play a role in opsonization of extracellular organisms, encapsulated bacteria in particular.
  • The marginal zone exists between the white pulp and red pulp.[1] It is located farther away from the central arteriole, in proximity to the red pulp. It contains antigen-presenting cells (APCs), such as dendritic cells and macrophages. Some of the white pulp's macrophages are of a specialized kind known as metallophilic macrophages.[2]
  1. ^ Cite error: The named reference den-Haan-and-Kraal-2012 was invoked but never defined (see the help page).
  2. ^ Cite error: The named reference Le-2018 was invoked but never defined (see the help page).

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