positive regulation of interferon-alpha production
MDA-5 signaling pathway
immune system process
response to virus
protein sumoylation
cytoplasmic pattern recognition receptor signaling pathway in response to virus
negative regulation of type I interferon production
detection of virus
viral process
innate immune response
regulation of type III interferon production
positive regulation of interferon-beta production
protein deubiquitination
positive regulation of response to cytokine stimulus
cellular response to exogenous dsRNA
defense response to virus
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
64135
71586
Ensembl
ENSG00000115267
ENSMUSG00000026896
UniProt
Q9BYX4
Q8R5F7
RefSeq (mRNA)
NM_022168
NM_001164477 NM_027835
RefSeq (protein)
NP_071451
NP_001157949 NP_082111
Location (UCSC)
Chr 2: 162.27 – 162.32 Mb
Chr 2: 62.43 – 62.48 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans.[5] MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor capable of detecting viruses. It is generally believed that MDA5 recognizes double stranded RNA (dsRNA) over 2000nts in length,[6] however it has been shown that whilst MDA5 can detect and bind to cytoplasmic dsRNA, it is also activated by a high molecular weight RNA complex composed of ssRNA and dsRNA.[7] For many viruses, effective MDA5-mediated antiviral responses are dependent on functionally active LGP2.[8] The signaling cascades in MDA5 is initiated via CARD domain.[9] Some observations made in cancer cells show that MDA5 also interacts with cellular RNA is able to induce an autoinflammatory response.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000115267 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026896 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: IFIH1 interferon induced with helicase C domain 1".
^Kato H, Takeuchi O, Mikamo-Satoh E, Hirai R, Kawai T, Matsushita K, et al. (July 2008). "Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5". The Journal of Experimental Medicine. 205 (7): 1601–10. doi:10.1084/jem.20080091. PMC 2442638. PMID 18591409.
^Pichlmair A, Schulz O, Tan CP, Rehwinkel J, Kato H, Takeuchi O, et al. (October 2009). "Activation of MDA5 requires higher-order RNA structures generated during virus infection". Journal of Virology. 83 (20): 10761–9. doi:10.1128/JVI.00770-09. PMC 2753146. PMID 19656871.
^Satoh T, Kato H, Kumagai Y, Yoneyama M, Sato S, Matsushita K, et al. (January 2010). "LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses". Proceedings of the National Academy of Sciences of the United States of America. 107 (4): 1512–7. Bibcode:2010PNAS..107.1512S. doi:10.1073/pnas.0912986107. PMC 2824407. PMID 20080593.
^Takeuchi O, Akira S (February 2008). "MDA5/RIG-I and virus recognition". Current Opinion in Immunology. 20 (1): 17–22. doi:10.1016/j.coi.2008.01.002. PMID 18272355.
^Dias Junior AG, Sampaio NG, Rehwinkel J (January 2019). "A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation". Trends in Microbiology. 27 (1): 75–85. doi:10.1016/j.tim.2018.08.007. PMC 6319154. PMID 30201512.
MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. MDA5...
immune systems. Three RLR helicases have so far been described: RIG-I and MDA5 (recognizing 5'triphosphate-RNA and dsRNA, respectively), which activate...
results in cleavage of all RNA in the cell. This can lead to activation of MDA5, an RNA helicase involved in the production of interferons. RNase L is present...
located in the endosomal membrane and recognize double-stranded RNA (dsRNA), MDA5 and RIG-I receptors are located in the cytoplasm and recognize long dsRNA...
membrane bound toll like receptors or the cytoplasmic receptors RIG-I or MDA5, can trigger release of IFNs. Toll Like Receptor 3 (TLR3) is important for...
antiviral responses against many viruses that are recognized by RIG-I and MDA5. Since LGP2 lacks CARD domains, its effect on downstream antiviral signaling...
the lowest value a radiation detector can measure within the human body MDA5, melanoma differentiation-associated protein 5 Mass drug administration 2...
(performed theme songs for The Gokusen, and Tottemo! Luckyman), dies from anti-MDA5 dermatomyositis and interstitial lung disease at age 73. Pineda, Rafael Antonio...
infected with EBOV, receptors located in the cell's cytosol (such as RIG-I and MDA5) or outside of the cytosol (such as Toll-like receptor 3 (TLR3), TLR7, TLR8...
state. HERV-derived dsRNA can be recognized by TLR-3, RIG-I and MDA5; RIG-I and MDA5 are known to induce a type I IFN response. When retrotranscribed...
MJ, et al. (January 2010). "Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in...
involve testing for other myositis-specific autoantibodies such as anti-MDA5 autoantibodies, anti-Mi-2 autoantibodies, and anti-signal recognition particle...
and later the RNA helicases, RIG-I (retinoic-acid-inducible protein I) and MDA5 (melanoma differentiation-associated protein 5). All molecules belong to...
can also be caused by mutations in other genes: TREX1, SAMHD1, ADAR, and MDA5/IFIH1, all of which are involved in nucleic acid processing. Characterization...
it is reported that she died on December 30, 2023 after a bout with anti-MDA5 dermatomyositis and rapidly progressing interstitial lung disease in a hospital...
viral protein processing but also cleave cytoplasmic recognition proteins MDA5 and RIG-I, further demonstrating the extent to which viruses can reduce Interferon...
triggered inflammatory signaling; that DAK, a dihydroacetone kinase, can inhibit MDA5; and that ISG56 (IFN-stimulated gene 56) is related to VSV replication, and...
Higuchi M, Hartner JC, et al. (September 2015). "RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself". Science. 349 (6252): 1115–1120....
through activating dsRNA expression which leads to the activation of the MDA5/MAVS RNA recognition pathway inducing some sort of viral mimicry inside the...
by DNA curvature. EMBO J. 31, 919-31. Ian C. Berke & Yorgo Modis (2012). MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded...
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