proteasome-mediated ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
80344
28199
Ensembl
ENSG00000100897 ENSG00000284796
ENSMUSG00000022214
UniProt
Q8TEB1
Q91VU6
RefSeq (mRNA)
NM_001163484 NM_025230 NM_181357
NM_001199009 NM_133734
RefSeq (protein)
NP_001156956 NP_079506 NP_852002
NP_001185938 NP_598495
Location (UCSC)
Chr 14: 24.11 – 24.13 Mb
Chr 14: 55.8 – 55.81 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
DDB1- and CUL4-associated factor 11 also known as WD Repeat Domain 23 (WDR23) is a protein that in humans is encoded by the DCAF11 gene.
DCAF11 is a WD40 repeat protein, containing seven repeats of the closed circular solenoid protein domain WD40.[5] WDR-23 exists in two spatially distinct isoforms produced by alternative splicing, a cytoplasmic WDR-23A and nuclear WDR-23B. Nuclear and cytoplasmic versions of WDR-23 have distinct roles.[6]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022214 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Choe KP, Przybysz AJ, Strange K (May 2009). "The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans". Molecular and Cellular Biology. 29 (10): 2704–2715. doi:10.1128/MCB.01811-08. PMC 2682033. PMID 19273594.
^Spatola BN, Lo JY, Wang B, Curran SP (August 2019). "Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates". Scientific Reports. 9 (1): 11783. Bibcode:2019NatSR...911783S. doi:10.1038/s41598-019-48286-y. PMC 6692315. PMID 31409866. This article incorporates text from this source, which is available under the CC BY 4.0 license.
Domain 23 (WDR23) is a protein that in humans is encoded by the DCAF11 gene. DCAF11 is a WD40 repeat protein, containing seven repeats of the closed...
(antisense) and PSME2 (sense). RNF31 is upstream and antisense to Fam158a. DCAF11 and FITM1 are both upstream of PSME1 antisense to Fam158a. PSME1 is a subunit...