H3K4me3 is an epigenetic modification to the DNA packaging protein Histone H3 that indicates tri-methylation at the 4th lysine residue of the histone H3 protein and is often involved in the regulation of gene expression.[1] The name denotes the addition of three methyl groups (trimethylation) to the lysine 4 on the histone H3 protein.
H3 is used to package DNA in eukaryotic cells (including human cells), and modifications to the histone alter the accessibility of genes for transcription. H3K4me3 is commonly associated with the activation of transcription of nearby genes. H3K4 trimethylation regulates gene expression through chromatin remodeling by the NURF complex.[2] This makes the DNA in the chromatin more accessible for transcription factors, allowing the genes to be transcribed and expressed in the cell. More specifically, H3K4me3 is found to positively regulate transcription by bringing histone acetylases and nucleosome remodelling enzymes (NURF).[3] H3K4me3 also plays an important role in the genetic regulation of stem cell potency and lineage.[4] This is because this histone modification is found more in areas of the DNA that are associated with development and establishing cell identity.[5]
^Sims RJ, Nishioka K, Reinberg D (November 2003). "Histone lysine methylation: a signature for chromatin function". Trends in Genetics. 19 (11): 629–39. doi:10.1016/j.tig.2003.09.007. PMID 14585615.
^Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, et al. (July 2006). "A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling". Nature. 442 (7098): 86–90. Bibcode:2006Natur.442...86W. doi:10.1038/nature04815. PMID 16728976. S2CID 4389087.
^Santos-Rosa H, Schneider R, Bernstein BE, Karabetsou N, Morillon A, Weise C, et al. (November 2003). "Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin". Molecular Cell. 12 (5): 1325–32. doi:10.1016/s1097-2765(03)00438-6. PMID 14636589.
^Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, et al. (April 2006). "A bivalent chromatin structure marks key developmental genes in embryonic stem cells". Cell. 125 (2): 315–26. CiteSeerX 10.1.1.328.9641. doi:10.1016/j.cell.2006.02.041. PMID 16630819. S2CID 9993008.
^Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, et al. (April 2006). "A bivalent chromatin structure marks key developmental genes in embryonic stem cells". Cell. 125 (2): 315–26. doi:10.1016/j.cell.2006.02.041. PMID 16630819.
H3K4me3 is an epigenetic modification to the DNA packaging protein Histone H3 that indicates tri-methylation at the 4th lysine residue of the histone...
marks on histone 3 lysine 4 (H3K4me3) and histone 3 lysine 27 (H3K27me3). The H3K27me3 mark silences the gene while the H3K4me3 mark allows the gene to not...
activity, where they catalyze the trimethylation of histone H3 lysine 4 (H3K4me3) and promote gene activation through histone acetylation. PcG and TrxG...
have been reported to bind to histone H3 tri-methylated on lysine 4 (H3K4me3), while other PHD fingers have tested negative in such assays. A protein...
ASH-2, lowers the levels of H3K4me3 and increases lifespan. Loss of the enzyme that demethylates H3K4me3, RB-2, increases H3K4me3 levels in C. elegans and...
interact in an antagonistic manner. H3K27me3 is often seen to interact with H3K4me3 in bivalent domains . These domains are usually found in embryonic stem...
different amounts of methylation. Modifications include: H3K4me1 H3K4me2 H3K4me3 This article includes a list of related items that share the same name...
or activation. For example, trimethylation of histone H3 at lysine 4 (H3K4me3) is an active mark for transcription and is upregulated in hippocampus...
This post-translational modification happens in conjunction with the H3K4me3 modification. The serotonylation potentiates the binding of the general...
RVE8-LNKs interaction enables a permissive histone-methylation pattern (H3K4me3) to be modified and the histone-modification itself parallels the oscillation...
Cyp33 RNA-recognition motif domain (RRM), and a PHD3 domain that binds to H3K4me3 or Cyp33 RRM. Cyp33 has the ability to downregulate the expression of these...
methylation and histone lysine methylation. For example, they indicated that H3K4me3 appears to block DNA methylation while H3K9me3 plays a role in promoting...
known as COMPASS, is a conserved protein complex playing a major role as a H3K4me3 methylase in eukaryotes. Since it was first identified in 2001, other members...
adult stem cells, also share similar epigenetic patterns. For example, H3K4me3 and H3K27me3, are two major histone methylation patterns that form a bivalent...
(histone nomenclature is described here): H2BK5ac H3K4me1 - primed enhancers H3K4me3 is enriched in transcriptionally active promoters. H3K9me2 -repression...
repaired by recombination with the homologous chromosome. PRDM9 deposits both H3K4me3 and H3K36me3 histone methylation marks at the sites it binds, and this...
Jing; Ye, Qunshan; Zhang, Zhan-Hui; Zhou, Qinghua (2022-02-09). "Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism...
demethylation of tri- and di-methylated lysines in the 4 position of histone 3 (H3K4me3 and H3K4me2). Jarid1B is a multidomain enzyme that is part of the subfamily...
pluripotent stem cells is still being assessed. Gene expression and genome-wide H3K4me3 and H3K27me3 were found to be extremely similar between ES and iPS cells...
Characteristic epigenetic rewiring in trained cells is the accumulation of H3K4me3 on immune genes promoters and the increase of H3k4me1 and H3K27ac on enhancers...
chromatin state. Chd1 helps maintain boundaries between histone modifications H3K4me3 and H3K36me3. It has also been shown that CHD1 is important in dictating...
aberrant histone products may be enriched with the activating modification H3K4me3. Additionally, upregulating histone deacetylases, such as members of the...
Françoijs KJ, Stunnenberg HG, Veenstra GJ (September 2009). "A hierarchy of H3K4me3 and H3K27me3 acquisition in spatial gene regulation in Xenopus embryos"...
of histones H3 and H4, decreased trimethylation of histone H3 Lysine 4 (H3K4me3), and increased monomethylation of histone H3 Lysine 9 (H3K9me1) and trimethylation...
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