Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections.[3] This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or Fusarium.[3] It can be taken by mouth or used by injection into a vein.[3]
Common side effects include vision problems, nausea, abdominal pain, rash, headache, and seeing or hearing things that are not present.[3] Use during pregnancy may result in harm to the baby.[3] It is in the triazole family of medications.[3] It works by affecting fungal metabolism and fungal cell membranes.[3]
Voriconazole was patented in 1990 and approved for medical use in the United States in 2002.[4][5] It is on the World Health Organization's List of Essential Medicines.[6]
^"Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
^Cite error: The named reference Vfend FDA label was invoked but never defined (see the help page).
^ abcdefg"Voriconazole". The American Society of Health-System Pharmacists. Retrieved 8 December 2017.
^Kendig EL, Wilmott RW, Chernick V (2012). Kendig and Chernick's Disorders of the Respiratory Tract in Children. Elsevier Health Sciences. p. 539. ISBN 978-1437719840.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 503. ISBN 9783527607495.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis...
up to year when the grains are black. Posaconazole is another option. Voriconazole can be used for infections caused by Fusarium species. Ketoconazole has...
be started with an initial loading dose include digoxin, teicoplanin, voriconazole, procainamide and fulvestrant. One or series of doses that may be given...
a broader spectrum of activity than fluconazole (but not as broad as voriconazole or posaconazole). In particular, it is active against Aspergillus, which...
further evaluation. Voriconazole is also being studied in salvage therapy for refractory cases. A case report indicated that voriconazole in combination with...
et al. (October 2021). "Impact of CYP2C19 genotype on voriconazole exposure and effect of voriconazole on the activity of CYP3A in patients with haematological...
voriconazole, posaconazole, and caspofungin; however, some antifungal resistance has been shown in amphotericin B, itraconazole, and voriconazole. In...
(April 2009). "Lack of allergic cross-reactivity between fluconazole and voriconazole" (PDF). Antimicrobial Agents and Chemotherapy. 53 (4): 1715–1716. doi:10...
October 2012). "Treatment of Granulomatous Amoebic Encephalitis with Voriconazole and Miltefosine in an Immunocompetent Soldier". The American Journal...
pharmacokinetics, analogues were developed. Second-generation triazoles, including voriconazole, posaconazole and ravuconazole, are more potent and more active against...
azoles is the triazoles, which includes fluconazole, itraconazole, and voriconazole. The difference between the imidazoles and the triazoles involves the...
guillermondii and C. rugosa. P. kudriavzevii can be successfully treated with voriconazole, amphotericin B, and echinocandins (micafungin, caspofungin, and anidulafungin)...
be used alternatively. Other oral triazoles, such as itraconazole and voriconazole can be other options. Amphotericin B can be used in nonresponsive cases...
current medical treatments for aggressive invasive aspergillosis include voriconazole and liposomal amphotericin B in combination with surgical debridement...
ampicillin bisacodyl clopidogrel delavirdine fluvoxamine iron salts voriconazole aminophylline and theophylline astemizole It is a racemic 1:1 mixture...
antifungal treatment, such as the use of terbinafine, itraconazole, voriconazole, and ketoconazole, is often effective. E. floccosum is one of the 2 species...
Hemoptysis, chest pain Chest X-ray and CT, microscopy by silver stains Voriconazole and liposomal amphotericin B in combination with surgical debridement...
treating invasive Aspergillus infection when used in combination with voriconazole. It is a member of the class of antifungal drugs known as the echinocandins;...
triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection...
person's bones and joints. The antifungal medications posaconazole and voriconazole have also been used to treat coccidioidomycosis. Because the symptoms...
fluconazole and a range of 3–73% of C. auris isolates are resistant to voriconazole, while other triazoles (posaconazole, itraconazole, and isavuconazole)...
with antifungals including fluconazole, griseofulvin, ketoconazole and voriconazole. (Topical use of these agents is thought to be safe due to minimal systemic...
classes of antifungals, especially of the azole class (fluconazole, voriconazole), increase tacrolimus levels by competing for cytochrome enzymes. Tacrolimus...
with one of CYP3A4 inhibitors such as itraconazole, telithromycin, and voriconazole, may increase serum concentrations of atorvastatin, which may lead to...
itraconazole; therefore, it shows promise as an alternative therapy. However, voriconazole susceptibility varies. Because the correlation between in vitro data...
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