Candida auris is a species of fungus that grows as yeast.[1] It is one of the few species of the genus Candida which cause candidiasis in humans. Often, candidiasis is acquired in hospitals by patients with weakened immune systems. C.auris can cause invasive candidiasis (fungemia) in which the bloodstream, the central nervous system, and internal organs are infected. It has attracted widespread attention because of its multiple drug resistance. Treatment is also complicated because it is easily misidentified as other Candida species.
Candida auris was first described in 2009 after it was isolated from the ear canal of a 70-year-old Japanese woman at the Tokyo Metropolitan Geriatric Hospital in Japan. In 2011, South Korea saw its first cases of disease-causing C.auris. Reportedly, this spread across Asia and Europe, and first appeared in the U.S. in 2013.[4]
DNA analysis of four distinct but drug-resistant strains of Candida auris indicate an evolutionary divergence taking place at least 4,000 years ago, with a common leap among the four varieties into drug-resistance possibly linked to widespread azole-type antifungal use in agriculture.[4] However, explanations for its emergence remain speculative.
^ abSatoh K, Makimura K, Hasumi Y, Nishiyama Y, Uchida K, Yamaguchi H (January 2009). "Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital". Microbiology and Immunology. 53 (1): 41–4. doi:10.1111/j.1348-0421.2008.00083.x. PMID 19161556.
^"Candida auris". DSMZ – German Collection of Microorganisms and Cell Cultures. Retrieved 1 August 2017.
^Casadevall A, Kontoyiannis DP, Robert V (July 2019). "On the Emergence of Candida auris: Climate Change, Azoles, Swamps, and Birds". mBio. 10 (4): e01397–19. doi:10.1128/mBio.01397-19. PMC 6650554. PMID 31337723.
^ abCite error: The named reference Richtel was invoked but never defined (see the help page).
Candidaauris is a species of fungus that grows as yeast. It is one of the few species of the genus Candida which cause candidiasis in humans. Often,...
fluconazole is common or due to increase in antibiotic use.[citation needed] Candidaauris is an emerging multidrug-resistant (MDR) yeast that can cause invasive...
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remaining cases. Recently, C. auris, a species first reported in 2009, has been found to cause invasive candidiasis. C. auris has attracted attention because...
Casadevall A, Kontoyiannis DP, Robert V (July 2019). "On the Emergence of Candidaauris: Climate Change, Azoles, Swamps, and Birds". mBio. 10 (4): 1786–1787...
identification have misidentified Candidaauris as Rhodotorula glutinis, until sequence analysis correctly identified C. auris as such. The genome of R. glutinis...
(138413A1). 2016. "Methods and pharmaceutical compositions for treating candidaauris in blood". Wipo (PCT). WO (126695A2). 2019. "Arginase formulations and...
the genus Candida. James, S. A.; Carvajal Barriga, E. J.; Bond, C. J.; Cross, K.; Núñez, N. C.; Portero, P. B.; Roberts, I. N. (2009). "Candida carvajalis...
pathogenic in humans include C. auris, C. tropicalis, C. parapsilosis, C. dubliniensis, and C. lusitaniae. The name Candida was proposed by Berkhout. It...
Klebsiella pneumoniae, Acinetobacter baumannii, Enterococcus faecium, Candidaauris, Escherichia coli and many others. Light is required to excite the photosensitizer...
Peak, S.S. Stous, J.M. Healy, et al. 2020 Factors Associated with Candidaauris Colonization and Transmission in Skilled Nursing Facilities with Ventilator...
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(20 October 2016). "Simultaneous Emergence of Multidrug-Resistant Candidaauris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological...
antifungal agents such as echinocandins and azoles. The emergence of Candidaauris as a potential human pathogen that sometimes exhibits multi-class antifungal...
infections, especially fungal infections caused by the drug-resistant fungus CandidaAuris, a species of fungus that grows as yeast. The fungus has spread through...
of United Kingdom Isolates of the Emerging Pathogen Candidaauris and Other Key Pathogenic Candida Species". mSphere. 1 (4). doi:10.1128/mSphere.00189-16...
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