Active site of the enzyme vanadium bromoperoxidase, which produces most of the earth's organobromine compounds.
Vanadium bromoperoxidases are a kind of enzymes called haloperoxidases. Its primary function is to remove hydrogen peroxide which is produced during photosynthesis from in or around the cell. By producing hypobromous acid (HOBr) a secondary reaction with dissolved organic matter, what results is the bromination of organic compounds that are associated with the defense of the organism. These enzymes produce the bulk of natural organobromine compounds in the world.
Vanadium bromoperoxidases are one of the few classes of enzymes that requires vanadium. The active site features a vanadium oxide center attached to the protein via one histidine side chain and a collection of hydrogen bonds to the oxide ligands.[1]
^Butler A, Carter-Franklin JN (February 2004). "The role of vanadium bromoperoxidase in the biosynthesis of halogenated marine natural products". Natural Product Reports. 21 (1): 180–8. doi:10.1039/b302337k. PMID 15039842.
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ocean, vanadium is used by some life forms as an active center of enzymes, such as the vanadiumbromoperoxidase of some ocean algae. Vanadium was discovered...
Vanadiumbromoperoxidases are a kind of enzymes called haloperoxidases. Its primary function is to remove hydrogen peroxide which is produced during photosynthesis...
algae (Rhodophyta and Phaeophyta) contain vanadate (vanadiumbromoperoxidase). Otherwise vanadium is unusual cofactor in biology. By virtue of this family...
compounds in the sea are made by the action of a unique algal enzyme, vanadiumbromoperoxidase. The bromide anion is not very toxic: a normal daily intake is...
crystallography. Vanadium(V) forms various peroxo complexes, most notably in the active site of the vanadium-containing bromoperoxidase enzymes. The species...
of Br+, a potent electrophile. The enzyme vanadiumbromoperoxidase, one of a larger family of bromoperoxidases, catalyzes this reaction in the marine environment...
covalently bound and becomes damaged during turnover. A specific vanadiumbromoperoxidase in marine organisms (fungi, bacteria, microalgae, perhaps other...
Butler, Alison; Carter-Franklin, Jayme N. (2004). "The role of vanadiumbromoperoxidase in the biosynthesis of halogenated marine natural products". Natural...
crystallography. Vanadium(V) forms various peroxo complexes, most notably in the active site of the vanadium-containing bromoperoxidase enzymes. The species...
relatively minor role in the global vanadium cycle. Vanadiumbromoperoxidase is present in some marine bacteria and algae. Vanadium can also takes the place of...
Butler, Alison; Carter-Franklin, Jayme N. (2004). "The role of vanadiumbromoperoxidase in the biosynthesis of halogenated marine natural products". Natural...
hetero-Diels-Alder to yield debromomarinone. Lastly, the vanadium-dependent bromoperoxidase catalyzes the bromination of debromomarinone at the C-5 position...
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