Distance metric used for comparing biological communities
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UniFrac, a shortened version of unique fraction metric, is a distance metric used for comparing biological communities. It differs from dissimilarity measures such as Bray-Curtis dissimilarity in that it incorporates information on the relative relatedness of community members by incorporating phylogenetic distances between observed organisms in the computation.
Both weighted (quantitative) and unweighted (qualitative) variants of UniFrac[1] are widely used in microbial ecology, where the former accounts for abundance of observed organisms, while the latter only considers their presence or absence. The method was devised by Catherine Lozupone, when she was working with Rob Knight[2] of the University of Colorado at Boulder in 2005.[3][4]
^Lozupone, C. A.; Hamady, M; Kelley, S. T.; Knight, R. (2007). "Quantitative and qualitative beta diversity measures lead to different insights into factors that structure microbial communities". Applied and Environmental Microbiology. 73 (5): 1576–85. doi:10.1128/AEM.01996-06. PMC 1828774. PMID 17220268.
^Knight, Rob (2015). Follow Your Gut: The Enormous Impact of Tiny Microbes. Simon & Schuster/TED. p. 89. ISBN 978-1-4767-8475-5.
^Lozupone, C.; Knight, R. (2005). "UniFrac: A New Phylogenetic Method for Comparing Microbial Communities". Applied and Environmental Microbiology. 71 (12): 8228–8235. doi:10.1128/AEM.71.12.8228-8235.2005. PMC 1317376. PMID 16332807.
^Hamady, M; Lozupone, C; Knight, R (2010). "Fast Uni Frac: Facilitating high-throughput phylogenetic analyses of microbial communities including analysis of pyrosequencing and Phylo Chip data". The ISME Journal. 4 (1): 17–27. doi:10.1038/ismej.2009.97. PMC 2797552. PMID 19710709.
UniFrac, a shortened version of unique fraction metric, is a distance metric used for comparing biological communities. It differs from dissimilarity...
data to analyse. Phylogenetic aware distance is usually performed with UniFrac or similar tools, such as Soresen's index or Rao's D, to quantify the differences...
sequences. Due to the complexity of the data, distance measures such as UniFrac distances are usually defined between microbiome samples, and downstream...
American microbiologist, working on the gut microbiome, who developed the UniFrac algorithm Silvia Maciá (born 1972), marine biologist Carolyn M. Mazure...
m ⋅ s = N m 2 ⋅ s = P a ⋅ s = {\displaystyle [\mu ]={\frac {\rm {kg}}{\rm {m{\cdot }s}}}={\frac {\rm {N}}{\rm {m^{2}}}}{\cdot }{\rm {s}}={\rm {Pa{\cdot...
e2/h represents the universal conductance. σ uni = ( π ) e 2 2 h {\displaystyle \sigma _{\text{uni}}={\frac {(\pi )e^{2}}{2h}}} (Equation 1) A representation...
by direction of the flow of information between its layers. Its flow is uni-directional, meaning that the information in the model flows in only one...
D u | u | . {\displaystyle F\,=\,C_{m}\,\rho \,{\frac {\pi }{4}}D^{2}\,{\dot {u}}\,+\,C_{d}\,{\frac {1}{2}}\,\rho \,D\,u\,|u|.} Besides the inline force...
{\displaystyle \operatorname {NPV} =-123400+{\frac {36200}{(1+r)^{1}}}+{\frac {54800}{(1+r)^{2}}}+{\frac {48100}{(1+r)^{3}}}=0.} In this case, the answer...
of the dielectric is. C = ε ⋅ A d {\displaystyle C=\varepsilon \cdot {\frac {A}{d}}} The dielectric thickness of electrolytic capacitors is very thin...
{\mathcal {E}}=-{\frac {d\Phi _{\mathbf {B} }}{dt}}=-{\frac {d}{dt}}(LI)} E = − L d I d t {\displaystyle \quad {\mathcal {E}}=-L{\frac {dI}{dt}}\quad }...
x or d d x f ( x ) . {\displaystyle {\frac {df}{dx}}(x){\text{ or }}{\frac {df(x)}{dx}}{\text{ or }}{\frac {d}{dx}}f(x).} Higher derivatives are written...