mitochondrial electron transport, ubiquinol to cytochrome c
protein processing involved in protein targeting to mitochondrion
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7385
67003
Ensembl
ENSG00000140740
ENSMUSG00000030884
UniProt
P22695
Q9DB77
RefSeq (mRNA)
NM_003366
NM_025899
RefSeq (protein)
NP_003357
NP_080175
Location (UCSC)
Chr 16: 21.95 – 21.98 Mb
Chr 7: 120.23 – 120.26 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2), also known as QCR2, UQCR2, or MC3DN5 is a protein that in humans is encoded by the UQCRC2 gene.[5] The product of UQCRC2 is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and "Rieske-associated protein."[6][7] Defects in UQCRC2 are associated with mitochondrial complex III deficiency, nuclear, type 5.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000140740 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030884 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: UQCRC2 ubiquinol-cytochrome c reductase core protein II".
^Duncan AM, Ozawa T, Suzuki H, Rozen R (November 1993). "Assignment of the gene for the core protein II (UQCRC2) subunit of the mitochondrial cytochrome bc1 complex to human chromosome 16p12". Genomics. 18 (2): 455–6. doi:10.1006/geno.1993.1500. PMID 8288258.
^Hosokawa Y, Suzuki H, Toda H, Nishikimi M, Ozawa T (August 1989). "Complementary DNA encoding core protein II of human mitochondrial cytochrome bc1 complex. Substantial diversity in deduced primary structure from its yeast counterpart". The Journal of Biological Chemistry. 264 (23): 13483–8. doi:10.1016/S0021-9258(18)80022-9. PMID 2547763.
mitochondrial (UQCRC2), also known as QCR2, UQCR2, or MC3DN5 is a protein that in humans is encoded by the UQCRC2 gene. The product of UQCRC2 is a subunit...
sapiens ubiquinol-cytochrome c reductase core protein I (UQCRC1), mRNA UQCRC2 NM_003366 UQCRHL NM_001089591 UQCRQ NM_014402 Homo sapiens low molecular...
gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes UQCRC1, UQCRC2, Cytochrome C1, UQCRFS1 (this protein, a type of Rieske protein), UQCRB...
subunit was present, along with oxidative modification of subunits UQCRC1 and UQCRC2 of the same core complex and UQCRH and CYC1 of the neighboring subcomplex...