oxidoreductase activity, acting on diphenols and related substances as donors
protein binding
Cellular component
integral component of membrane
membrane
mitochondrial membranes
myelin sheath
mitochondrion
mitochondrial inner membrane
respirasome
mitochondrial respiratory chain complex III
mitochondrial respiratory chain complex IV
Biological process
proton transmembrane transport
response to antibiotic
response to hormone
mitochondrial electron transport, ubiquinol to cytochrome c
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7386
66694
Ensembl
ENSG00000169021
ENSMUSG00000038462
UniProt
P47985
Q9CR68
RefSeq (mRNA)
NM_006003
NM_025710
RefSeq (protein)
NP_005994
NP_079986
Location (UCSC)
Chr 19: 29.21 – 29.21 Mb
Chr 13: 30.72 – 30.73 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1, also known as UQCRFS1, Rieske iron-sulfur (Fe-S) protein, Cytochrome b-c1 complex subunit 5, or Complex III subunit 5 is a protein which in humans is encoded by the UQCRFS1 gene.[5] UQCRFS1 is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes UQCRC1, UQCRC2, Cytochrome C1, UQCRFS1 (this protein, a type of Rieske protein), UQCRB,UQCRQ ("11kDa protein"), UQCRH (cyt c1 Hinge protein), UCRC ("cyt. c1 associated protein"), and UQCR ("Rieske-associated protein").[6]
^ abcGRCh38: Ensembl release 89: ENSG00000169021 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000038462 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1". This article incorporates text from this source, which is in the public domain.
^Cite error: The named reference Uniprot was invoked but never defined (see the help page).
Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1, also known as UQCRFS1, Rieske iron-sulfur (Fe-S) protein, Cytochrome b-c1 complex subunit 5,...
Rieske protein (UQCRFS1). It also participates in the clearance of UQCRFS1 N-terminal fragments which are produced by the addition of UQCRFS1 into the Ubiquinol...
gene is a nuclear-encoded mitochondrial matrix protein that stabilizes UQCRFS1 and chaperones it to the CIII complex. Defects in this gene are a cause...
includes the respiratory subunits cytochrome b, cytochrome c1 (CYC1), UQCRFS1, the core proteins UQCRC1 and UQCRC2, and the low-molecular weight proteins...