positive regulation of melanin biosynthetic process
pigmentation
metabolism
melanocyte differentiation
acetoacetic acid metabolic process
melanin biosynthetic process
response to thyroid hormone
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7306
22178
Ensembl
ENSG00000107165
ENSMUSG00000005994
UniProt
P17643
P07147
RefSeq (mRNA)
NM_000550
NM_001282014 NM_001282015 NM_031202
RefSeq (protein)
NP_000541
NP_001268943 NP_001268944 NP_112479
Location (UCSC)
Chr 9: 12.69 – 12.71 Mb
Chr 4: 80.75 – 80.77 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Tyrosinase-related protein 1, also known as TYRP1, is an intermembrane enzyme which in humans is encoded by the TYRP1 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000107165 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000005994 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^EntrezGene 7306
^Box NF, Wyeth JR, Mayne CJ, O'Gorman LE, Martin NG, Sturm RA (January 1998). "Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1". Mammalian Genome. 9 (1): 50–53. doi:10.1007/s003359900678. PMID 9434945. S2CID 10020827.
Tyrosinase-related protein 1, also known as TYRP1, is an intermembrane enzyme which in humans is encoded by the TYRP1 gene. Tyrp1 is a melanocyte-specific gene product...
Melanesians is caused by a recessive mutation in tyrosinase-related protein 1 (TYRP1). In the Solomon Islands, 26% of the population carry the gene; however...
Australia, known to have blond hair. The blond trait developed via the TYRP1 gene, which is not the same gene that causes blondness in European blonds...
Li; Bed'hom; Marthay; et al. (20 November 2018). "A missense mutation in TYRP1 causes the chocolate plumage color in chicken and alters melanosome structure"...
the TYRP1 gene, and since mammals have two copies of each gene, one from each parent, an animal with at least one copy of the fully functioning TYRP1 protein...
Albinism may be caused by a number of other genes as well, like OCA2, SLC45A2, TYRP1, and HPS1 to name some. In all, already 17 types of oculocutaneous albinism...
Blond hair in Melanesians is caused by an amino acid change in the gene TYRP1. This mutation is at a frequency of 26% in the Solomon Islands and is absent...
Li; Bed'hom; Marthay; et al. (20 November 2018). "A missense mutation in TYRP1 causes the chocolate plumage color in chicken and alters melanosome structure"...
E, et al., "Melanesian Blond Hair Is Caused by an Amino Acid Change in TYRP1", Science, 4 May 2012, Vol. 336 no. 6081 p. 554. "Journal of the Polynesian...
the stereotypical coat of a Siamese. The browning gene B/b/bl codes for TYRP1 (Q4VNX8), an enzyme involved in the metabolic pathway for eumelanin pigment...
related protein 1 (TYRP1). This gene affects the color of the eumelanin pigment produced, making it either black or brown. TYRP1 is an enzyme involved...
2005). The color of a Dalmatian's spots: Linkage evidence to support the TYRP1 gene. Vol. 1. p. 1. doi:10.1186/1746-6148-1-1. ISBN 978-1-74661-481-2. PMC 1192828...
differentiation as well as the transcription of melanogenic enzymes (tyrosinase, TYRP1, and TYRP2) and melanosome structural proteins (MART-1 and PMEL17) [references...
OCA3 203290 TYRP1 Has only been partially researched and documented. It is caused by mutation of the tyrosinase-related protein-1 (Tyrp1) gene. Cases...
a "selective sweep" during the Mesolithic (19 to 11 ka). The associated TYRP1 SLC24A5 and SLC45A2 alleles emerge around 19 ka, still during the LGM, most...
monoclonal antibody designed for the treatment of melanoma. It targets TYRP1. Flanvotumab was developed by ImClone Systems, now owned by Eli Lilly. "Statement...
and apparently arose already in bacteria. The tyrosinase related protein (Tyrp1) and dopachrome tautomerase (Dtc), which encode for protein implicated in...
descent emerged during the LGM, from about 19,000 years ago. The associated TYRP1 SLC24A5 and SLC45A2 alleles emerge around 19,000 years ago, still during...
"Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus)"...
genes of large effect as well as several other genes of small effect (TYR, TYRP1, OCA2, SLC45A2, SLC24A5, MC1R, KITLG and SLC24A4). This does not take into...
published Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus)...
"Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus)"...
microphthalmia-associated transcription factor (MITF). Tyrosinase-related protein 1 (TYRP1) Dopachrome, a cyclization product of L-DOPA and is an intermediate in the...
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