Bacterial type II and III secretion system protein
Identifiers
Symbol
Secretin
Pfam
PF00263
InterPro
IPR004846
TCDB
3.A.5
OPM superfamily
348
OPM protein
5wln
Membranome
430
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
The type 2 secretion system (often referred to as the type II secretion system or by the initials T2SS) is a type of protein secretion machinery found in various species of Gram-negative bacteria, including many human pathogens such as Pseudomonas aeruginosa and Vibrio cholerae.[1] The type II secretion system is one of six protein secretory systems commonly found in Gram-negative bacteria, along with the type I, type III, and type IV secretion systems, as well as the chaperone/usher pathway, the autotransporter pathway/type V secretion system, and the type VI secretion system (some bacteria also utilize the type VII secretion system).[2] Like these other systems, the type II secretion system enables the transport of cytoplasmic proteins across the lipid bilayers that make up the cell membranes of Gram-negative bacteria. Secretion of proteins and effector molecules out of the cell plays a critical role in signaling other cells and in the invasion and parasitism of host cells.
^Douzi B, Filloux A, Voulhoux R (2012). "On the path to uncover the bacterial type II secretion system". Philosophical Transactions of the Royal Society B: Biological Sciences. 367 (1592): 1059–1072. doi:10.1098/rstb.2011.0204. PMC 3297435. PMID 22411978.
^Tseng T, Tyler BM, Setubal JC (2009). "Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology". BMC Microbiology. 9: S2. doi:10.1186/1471-2180-9-S1-S2. PMC 2654662. PMID 19278550.
and 27 Related for: Type II secretion system information
compose the full secretion apparatus, many with as yet unknown function. Gram-negative type IV pili use a modified version of the typeIIsystem for their biogenesis...
Bacterial secretionsystems are protein complexes present on the cell membranes of bacteria for secretion of substances. Specifically, they are the cellular...
to the type IV secretionsystem (T4SS). They can be classified into the F-like type (after the F-pilus) and the P-like type. Like their secretion counterparts...
extremely large: 25-30 nm in diameter. All CDCs are secreted by the typeIIsecretionsystem; the exception is pneumolysin, which is released from the cytoplasm...
the only known intracellular pathogen to have a TypeIISecretionSystem (secretome). In TypeIISecretion, proteins are first translocated across the inner...
PMID 16497587. S2CID 15418509. Cianciotto NP (December 2005). "TypeIIsecretion: a protein secretionsystem for all seasons". Trends in Microbiology. 13 (12): 581–88...
assembled through the TypeIIsecretionsystem. They can also promote swimming, but no species of bacteria is known to use its Type IV pili for both swimming...
(exported by the typeIIsecretionsystem), polysaccharides, lipopolysaccharides, a fatty acid-dependent cell-cell communication system, and proteins (secreted...
archaella, type IV pili, typeIIsecretionsystems, and the Tad pili. Complexes in the TFF superfamily are unified by the presence of the eponymous type IV pilin...
regulates aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Angiotensin II receptor blockers...
the central nervous system. However, not all people with insulin resistance develop diabetes since an impairment of insulin secretion by pancreatic beta...
thus causing the secretion of glucagon from the pancreas. High levels of glucagon secretion has been implicated in both Type I and TypeII diabetes. In fact...
enzyme Type III intermediate filaments, structural proteins Type III secretionsystem used by pathogenic bacteria Type III von Neumann algebra Type III sums...
related to the type IV pilus is the typeIIsecretionsystem, itself widely distributed amongst gram-negative bacteria. In this secretionsystem, cargo destined...
transfusions, it is the most important of the 44 different blood type (or group) classification systems currently recognized by the International Society of Blood...
controls secretion of pituitary gland hormones, and has subsequently expanded to investigate numerous interconnections of the endocrine and nervous systems. The...
in a dose-dependent fashion. This system of release is commonly referred to as glucose-stimulated insulin secretion (GSIS). There are four key pieces...
arterial smooth muscle to cause vasoconstriction. Angiotensin II also increases aldosterone secretion; it therefore acts as an endocrine, autocrine/paracrine...
multiple downstream pathways to trigger pyroptosis and secretion of pro-inflammatory cytokines. Types of proteins containing a PYD include an adaptor, apoptosis-associated...
glucagon-mediated rescue of glucose levels. Onset of type 1 diabetes is followed by an increase in glucagon secretion after meals. Increases have been measured up...
primarily categorized into type I and typeII, where typeII neurons are multipolar with numerous long, smooth processes, and type I neurons feature numerous...
components of type IV pili, which are assembled through the action of typeIIsecretionsystems (the nomenclature of pili and protein secretionsystems is not...
common ancestor, from where it diversified into archaella, Type IV Pili, TypeIISecretionSystems, and the Tad pili. The first observations of what is now...
insulin resistance are known to be involved. Type 2 diabetes is characterized by increased glucagon secretion which is unaffected by, and unresponsive to...
phase. The first stage, the cephalic phase of digestion, begins with secretions from gastric glands in response to the sight and smell of food. This stage...
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