Transitional B cells are B cells at an intermediate stage in their development between bone marrow immature cells and mature B cells in the spleen. Primary B cell development takes place in the bone marrow, where immature B cells must generate a functional B cell receptor (BCR) and overcome negative selection induced by reactivity with autoantigens.[1] Transitional cells can be found in the bone marrow, peripheral blood, and spleen, and only a fraction of the immature B cells that survive after the transitional stage become mature B cells in secondary lymphoid organs such as the spleen.
^Sims GP, Ettinger R, Shirota Y, Yarboro CH, Illei GG, Lipsky PE (1 June 2005). "Identification and characterization of circulating human transitional B cells". Blood. 105 (11): 4390–8. doi:10.1182/blood-2004-11-4284. PMC 1895038. PMID 15701725.
and 26 Related for: Transitional B cell information
TransitionalBcells are Bcells at an intermediate stage in their development between bone marrow immature cells and mature Bcells in the spleen. Primary...
migrate from the bone marrow into the spleen as transitionalBcells, passing through two transitional stages: T1 and T2. Throughout their migration to...
Transitional epithelium is a type of stratified epithelium. Transitional epithelium is a type of tissue that changes shape in response to stretching (stretchable...
Transitionalcell carcinoma, also called urothelial carcinoma, is a type of cancer that typically occurs in the urinary system. It is the most common...
adult human body is estimated to contain about 30 trillion (3×1013) human cells, with the number varying between 20 to 40 trillion depending on factors...
Bcells and lower frequencies of class-switched memory Bcells. Frequencies of other Bcell populations, such as IgD memory Bcells, transitionalB cells...
but, generally, immature Bcells migrate to the spleen for 'higher education' of some sort where they go through transitional stages before final maturation...
hysteresis in this cell cycle transition. At the intermediate cyclin B concentrations, either the interphase or mitotic state of the cell is possible. Since...
peripheral blood mononucleated cells are polyclonal naïve mature Bcells, with a significant increase in immature, transitionalBcell numbers (identified as...
CD4+ T lymphocytopenia is associated with increases in immature/transitionalBcells and serum levels of IL-7". Blood. 109 (5): 2086–8. doi:10.1182/blood-2006-06-031385...
therefore described as pseudostratified columnar epithelium. Transitional epithelium has cells that can change from squamous to cuboidal, depending on the...
(Scheherazade Sadegh-Nasseri & Ronald N. Germain) 1992 – Discovery of transitionalBcells (David Allman & Michael Cancro) 1994 – Danger model of immunological...
multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely...
know exactly how close a transitional fossil is to the point of divergence. Therefore, it cannot be assumed that transitional fossils are direct ancestors...
if the cell can progress to the next phase. In cells without nuclei the prokaryotes, bacteria and archaea, the cell cycle is divided into the B, C, and...
-əts) constitute the domain of Eukarya or Eukaryota, organisms whose cells have a membrane-bound nucleus. All animals, plants, fungi, and many unicellular...
Cell division is the process by which a parent cell divides into two daughter cells. Cell division usually occurs as part of a larger cell cycle in which...
platelets. Lymphoid cells include T cells, Bcells, natural killer cells, and innate lymphoid cells. The definition of hematopoietic stem cell has developed...
continuation of the cell cycle requires persisting oscillations in cyclin-B/CDK1 activity as the cell and its descendants transition in and out of M-phase...
alveoli. The cells in the respiratory epithelium are of five main types: a) ciliated cells, b) goblet cells, c) brush cells, d) airway basal cells, and e)...
A fuel cell is an electrochemical cell that converts the chemical energy of a fuel (often hydrogen) and an oxidizing agent (often oxygen) into electricity...
A solar cell or photovoltaic cell (PV cell) is an electronic device that converts the energy of light directly into electricity by means of the photovoltaic...
antigen-presenting cells, such as dendritic cells, and B lymphocytes. M cells express the protease cathepsin E, similar to other antigen-presenting cells. This process...
Natural killer cells, also known as NK cells or large granular lymphocytes (LGL), are a type of cytotoxic lymphocyte critical to the innate immune system...
Global Information