Tocolytics (also called anti-contraction medications or labor suppressants) are medications used to suppress premature labor (from Greek τόκος tókos, "childbirth", and λύσις lúsis, "loosening"). Preterm birth accounts for 70% of neonatal deaths.[1] Therefore, tocolytic therapy is provided when delivery would result in premature birth, postponing delivery long enough for the administration of glucocorticoids, which accelerate fetal lung maturity but may require one to two days to take effect.
Commonly used tocolytic medications include β2 agonists, calcium channel blockers, NSAIDs, and magnesium sulfate. These can assist in delaying preterm delivery by suppressing uterine muscle contractions and their use is intended to reduce fetal morbidity and mortality associated with preterm birth.[2] The suppression of contractions is often only partial and tocolytics can only be relied on to delay birth for a matter of days. Depending on the tocolytic used, the pregnant woman or fetus may require monitoring (e.g., blood pressure monitoring when nifedipine is used as it reduces blood pressure; cardiotocography to assess fetal well-being). In any case, the risk of preterm labor alone justifies hospitalization.
^American College of Obstetricians Gynecologists' Committee on Practice Bulletins—Obstetrics (2016). "Practice Bulletin No. 171: Management of Preterm Labor". Obstetrics & Gynecology. 128 (4): e155–e164. doi:10.1097/AOG.0000000000001711. ISSN 0029-7844. PMID 27661654. S2CID 5537988.
^Mayer, Christopher; Apodaca-Ramos, Irasema (2021), "Tocolysis", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 32965883, retrieved 29 July 2021
Tocolytics (also called anti-contraction medications or labor suppressants) are medications used to suppress premature labor (from Greek τόκος tókos, "childbirth"...
as a "reliever" inhaler in the management of asthma symptoms and as a tocolytic (anti-contraction medication) to delay preterm labor for up to 48 hours...
Isoxsuprine is used in humans for treatment of premature labor, i.e. a tocolytic, and as a vasodilator for the treatment of cerebral vascular insufficiency...
The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications...
Ritodrine (trade name Yutopar) is a tocolytic drug used to stop premature labor. This drug has been removed from the US market, according to FDA Orange...
vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. It was developed by Ferring Pharmaceuticals...
commonly used for smooth muscle-relaxant properties as a bronchodilator and tocolytic. It is classified by the World Anti-Doping Agency as an anabolic agent...
is also used in some countries (such as Russia and Switzerland) as a tocolytic agent (i.e., labor suppressant), with the most common trade name being...
phenytoin it results in better outcomes. Magnesium sulfate was once used as a tocolytic, but meta-analyses have failed to support it as an anti-contraction medication...
abnormal fetal heart rate persists, and uterine tachysystole continues, tocolytic remedies, such as terbutaline, may be used. Afterward, if beneficial and...
which tocolytic drug is safer for the patient. An emergency delivery or cesarean section may also be an effective treatment option, tocolytic drugs are...
cause uterine contractions in pregnant women. Indometacin is an effective tocolytic agent, able to delay premature labor by reducing uterine contractions...
the pulmonary system, safety in patients with hyperthyroidism and non-tocolytic pharmacological properties. Additionally, by maintaining patient's consciousness...
in the treatment of asthma, preventing eclampsia and cerebral palsy, a tocolytic agent, and as an anticonvulsant. It also may be used as laxative. In agriculture...
Margioula-Siarkou C, Kalogiannidis I (April 2016). "Effectiveness of Tocolytic Agents on Prevention of Preterm Delivery, Neonatal Morbidity, and Mortality:...
salbutamol also has use in obstetrics. Intravenous salbutamol can be used as a tocolytic to relax the uterine smooth muscle to delay premature labor. While preferred...
dysreflexia in spinal cord injury. Nifedipine has been used frequently as a tocolytic (agent that delays premature labor). A Cochrane review has concluded that...
Preventative tocolysis (medications to prevent contractions): the use of tocolytic medications to prevent labor contractions is controversial. On the one...
which might affect the success of an ECV. Drugs called beta-stimulant tocolytics help the woman's muscles to relax so that the pressure during the ECV...
called tocolytics. Tocolytics delay labour by inhibiting contractions of the uterine muscles that progress labour. The most widely used tocolytics include...
results for the treatment of Raynaud's disease and dysmenorrhoea, and as a tocolytic, although it is not yet approved for clinical use. Lemmens-Gruber R, Kamyar...
week after the procedure. There is no need for chronic administration of tocolytic agents since postoperative uterine contractions are barely ever observed...
delivery. There is some evidence to support the use of tocolytic drugs in ECV. Given by injection, tocolytics relax the uterus muscle and may improve the chance...
hyperstimulation and to minimize the effects on Fetal Heart Rate. Administration of tocolytic treatment with β2-adrenergic drugs has shown to stabilize uterine contractions...
Magnesium citrate are metal-organic compounds formed from citrate and magnesium ions. They are salts. One form is the 1:1 magnesium preparation in salt...
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