Tiletamine information

Tiletamine
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	IV, IM, SC, Other
ATC code	none;
Legal status
Legal status	AU: S4 (Prescription only); US: Schedule III (when combined with Zolazepam);
Pharmacokinetic data
Metabolism	Liver
Excretion	Kidneys
Identifiers
	IUPAC name 2-Ethylamino-2-(2-thienyl)cyclohexanone;
CAS Number	14176-49-9 ; HCl: 14176-50-2 ;
PubChem CID	26533;
ChemSpider	24714 ;
UNII	2YFC543249; HCl: 99TAQ2QWJI ;
KEGG	D08596 ;
CompTox Dashboard (EPA)	DTXSID5048552 ;
ECHA InfoCard	100.034.559
Chemical and physical data
Formula	C12H17NOS
Molar mass	223.33 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2C(c1sccc1)(NCC)CCCC2;
	InChI InChI=1S/C12H17NOS/c1-2-13-12(11-7-5-9-15-11)8-4-3-6-10(12)14/h5,7,9,13H,2-4,6,8H2,1H3 ; Key:QAXBVGVYDCAVLV-UHFFFAOYSA-N ;
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Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist.^[1] It is related chemically to ketamine.^[2] Tiletamine hydrochloride exists as odorless white crystals.

It is used in veterinary medicine in the combination product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs.^[3]^[4]^[5] It is sometimes used in combination with xylazine (Rompun) to chemically immobilize large mammals such as polar bears^[6] and wood bison.^[7] Telazol is the only commercially available tiletamine product in the United States. It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.^[3]

^ Klockgether T, Turski L, Schwarz M, Sontag KH, Lehmann J (October 1988). "Paradoxical convulsant action of a novel non-competitive N-methyl-D-aspartate (NMDA) antagonist, tiletamine". Brain Research. 461 (2): 343–348. doi:10.1016/0006-8993(88)90265-X. PMID 2846121. S2CID 41671395.
^ CID 26533 from PubChem
^ ^a ^b "Tiletamine". Drugs.com. Retrieved 5 January 2012.
^ Lin HC, Thurmon JC, Benson GJ, Tranquilli WJ (December 1993). "Telazol--a review of its pharmacology and use in veterinary medicine". Journal of Veterinary Pharmacology and Therapeutics. 16 (4): 383–418. doi:10.1111/j.1365-2885.1993.tb00206.x. PMID 8126757.
^ "Tiletamine". Toxnet. U.S. National Library of Medicine. 21 January 2009.
^ Cattet MR, Caulkett NA, Lunn NJ (July 2003). "Anesthesia of polar bears using xylazine-zolazepam-tiletamine or zolazepam-tiletamine". Journal of Wildlife Diseases. 39 (3): 655–664. doi:10.7589/0090-3558-39.3.655. PMID 14567228.
^ Caulkett NA, Cattet MR, Cantwell S, Cool N, Olsen W (January 2000). "Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations". The Canadian Veterinary Journal. 41 (1): 49–53. doi:10.4141/cjas61-007. PMC 1476335. PMID 10642872.

[1] Klockgether T, Turski L, Schwarz M, Sontag KH, Lehmann J (October 1988). "Paradoxical convulsant action of a novel non-competitive N-methyl-D-aspartate (NMDA) antagonist, tiletamine". Brain Research. 461 (2): 343–348. doi:10.1016/0006-8993(88)90265-X. PMID 2846121. S2CID 41671395.

[2] CID 26533 from PubChem

[Tiletamine-3] "Tiletamine". Drugs.com. Retrieved 5 January 2012.

[4] Lin HC, Thurmon JC, Benson GJ, Tranquilli WJ (December 1993). "Telazol--a review of its pharmacology and use in veterinary medicine". Journal of Veterinary Pharmacology and Therapeutics. 16 (4): 383–418. doi:10.1111/j.1365-2885.1993.tb00206.x. PMID 8126757.

[5] "Tiletamine". Toxnet. U.S. National Library of Medicine. 21 January 2009.

[6] Cattet MR, Caulkett NA, Lunn NJ (July 2003). "Anesthesia of polar bears using xylazine-zolazepam-tiletamine or zolazepam-tiletamine". Journal of Wildlife Diseases. 39 (3): 655–664. doi:10.7589/0090-3558-39.3.655. PMID 14567228.

[7] Caulkett NA, Cattet MR, Cantwell S, Cool N, Olsen W (January 2000). "Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations". The Canadian Veterinary Journal. 41 (1): 49–53. doi:10.4141/cjas61-007. PMC 1476335. PMID 10642872.

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Clinical data


AHFS/Drugs.com	International Drug Names
Routes of administration	IV, IM, SC, Other
ATC code	none
Legal status
Legal status	AU: S4 (Prescription only) US: Schedule III (when combined with Zolazepam)
Pharmacokinetic data
Metabolism	Liver
Excretion	Kidneys
Identifiers
IUPAC name 2-Ethylamino-2-(2-thienyl)cyclohexanone
CAS Number	14176-49-9^Y HCl: 14176-50-2^Y
PubChem CID	26533
ChemSpider	24714^Y
UNII	2YFC543249 HCl: 99TAQ2QWJI^Y
KEGG	D08596^Y
CompTox Dashboard (EPA)	DTXSID5048552
ECHA InfoCard	100.034.559
Chemical and physical data
Formula	C₁₂H₁₇NOS
Molar mass	223.33 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C2C(c1sccc1)(NCC)CCCC2
InChI InChI=1S/C12H17NOS/c1-2-13-12(11-7-5-9-15-11)8-4-3-6-10(12)14/h5,7,9,13H,2-4,6,8H2,1H3^Y Key:QAXBVGVYDCAVLV-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)