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Chemical compound
Thioflavins are fluorescent dyes that are available as at least two compounds, namely Thioflavin T and Thioflavin S. Both are used for histology staining and biophysical studies of protein aggregation.[1] In particular, these dyes have been used since 1989 to investigate amyloid formation.[2] They are also used in biophysical studies of the electrophysiology of bacteria.[3] Thioflavins are corrosive, irritant, and acutely toxic, causing serious eye damage.[4] Thioflavin T has been used in research into Alzheimer's disease and other neurodegenerative diseases.
^Biancalana M, Koide S (July 2010). "Molecular mechanism of Thioflavin-T binding to amyloid fibrils". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1804 (7): 1405–12. doi:10.1016/j.bbapap.2010.04.001. PMC 2880406. PMID 20399286.
^Gade Malmos, Kirsten; Blancas-Mejia, Luis M.; Weber, Benedikt; Buchner, Johannes; Ramirez-Alvarado, Marina; Naiki, Hironobu; Otzen, Daniel (2017). "THT 101: A primer on the use of thioflavin T to investigate amyloid formation". Amyloid. 24 (1): 1–16. doi:10.1080/13506129.2017.1304905. PMID 28393556.
^Prindle A, Liu J, Asally M, Ly S, Garcia-Ojalvo J, Süel GM (November 2015). "Ion channels enable electrical communication in bacterial communities". Nature. 527 (7576): 59–63. Bibcode:2015Natur.527...59P. doi:10.1038/nature15709. PMC 4890463. PMID 26503040.
^"Thioflavin T". National Center for Biotechnology Information. PubChem.
Thioflavins are fluorescent dyes that are available as at least two compounds, namely Thioflavin T and Thioflavin S. Both are used for histology staining...
Pittsburgh compound B (PiB) is a radioactive analog of thioflavin T, which can be used in positron emission tomography scans to image beta-amyloid plaques...
and an ability to stain with specific dyes, such as Congo red, thioflavin T or thioflavin S. The term "cross-β" was based on the observation of two sets...
fluorimetry equipment. Thioflavins are dyes used for histology staining and biophysical studies of protein aggregation. For example, thioflavin T is used in the...
solanezumab. Imaging compounds, notably Pittsburgh compound B, (6-OH-BTA-1, a thioflavin), can selectively bind to amyloid beta in vitro and in vivo. This technique...
confocal microscopy, Congo red can be used as a stable fluorescent stain. Thioflavin Klaus Hunger, Peter Mischke, Wolfgang Rieper, Roderich Raue, Klaus Kunde...
fluorescent. Thioflavin T is obtained by the methylation of dehydrothiotoluidine with methanol in the presence of hydrochloric acid. Thioflavin S results...
electron-withdrawing moiety with numerous applications in dyes such as thioflavin. Some drugs contain this group, examples being riluzole and pramipexole...
light, makes the amyloid proteins appear apple-green on microscopy. Also, thioflavin T stain may be used. A number of imaging techniques such as a Nuclear...
same core structure as amyloid fibrils, and is positive to Congo red and thioflavin T. The monolayer formed by class I hydrophobins has a highly ordered structure...
a variety of staining techniques, including silver stains, Congo red, Thioflavin, cresyl violet, PAS-reaction, and luminescent conjugated oligothiophenes...
human brain using PET scanning, and which is a fluorescent analog of thioflavin T. For his work on Alzheimer's disease he has received the Metlife Foundation...
g/mol) may refer to: Chlorpromazine, the oldest typical antipsychotic Thioflavin, two dyes used for histology staining This set index page lists chemical...
Krebs, M.R.H.; Bromley, E.H.C.; Donald, A.M. (2005). "The binding of thioflavin-T to amyloid fibrils: Localisation and implications". Journal of Structural...
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