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Tacalcitol information


Tacalcitol
Clinical data
Other names(1α,24R)-1,24-Dihydroxyvitamin D3
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Topical
ATC code
  • D05AX04 (WHO)
Identifiers
IUPAC name
  • (1S,3R,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-1,3,24-triol
CAS Number
  • 57333-96-7 checkY
PubChem CID
  • 5283734
IUPHAR/BPS
  • 2780
ChemSpider
  • 4446823 ☒N
UNII
  • C2W72OJ5ZU
ChEBI
  • CHEBI:32176
ChEMBL
  • ChEMBL340361 ☒N
CompTox Dashboard (EPA)
  • DTXSID90905111 Edit this at Wikidata
ECHA InfoCard100.220.855 Edit this at Wikidata
Chemical and physical data
FormulaC27H44O3
Molar mass416.646 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)C)C
InChI
  • InChI=1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1 ☒N
  • Key:BJYLYJCXYAMOFT-RSFVBTMBSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Tacalcitol (1,24-dihydroxyvitamin D3) is a synthetic vitamin D3 analog.[1] Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.

It is on the World Health Organization's List of Essential Medicines.[2]

  1. ^ Peters DC, Balfour JA (August 1997). "Tacalcitol". Drugs. 54 (2): 265–71, discussion 272. doi:10.2165/00003495-199754020-00005. PMID 9257082. S2CID 263503145.
  2. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

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Tacalcitol

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Tacalcitol (1,24-dihydroxyvitamin D3) is a synthetic vitamin D3 analog. Tacalcitol is marketed under several names, including Curatoderm and Bonalfa. It...

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Vitamin D analogues

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Calcipotriol (calcipotriene) Doxercalciferol Falecalcitriol Paricalcitol Tacalcitol These modified vitamin D analogues have side chain or other modifications...

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WHO Model List of Essential Medicines

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chemical subgroup (D07AA Corticosteroids, weak (group I)) Calcitriol and tacalcitol are alternatives Podophyllotoxin is an alternative precipitated sulfur...

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Vitamin D

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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Psoriatic onychodystrophy

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topical, intralesional, radiation, systemic, and combination therapies. Tacalcitol ointment obtains a significant improvement in all nail parameters, both...

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Cholecalciferol

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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Ergocalciferol

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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Calcifediol

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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Alfacalcidol

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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Calcipotriol

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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Calcitriol

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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Dihydroxyvitamin D3

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25-dihydroxyvitamin D3) 24,25-Dihydroxycholecalciferol (24,25-dihydroxyvitamin D3) Tacalcitol (1,24-dihydroxyvitamin D3) This disambiguation page lists articles associated...

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Maxacalcitol

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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Vitamin D receptor

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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Eldecalcitol

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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ATC code D05

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D05AX01 Fumaric acid D05AX02 Calcipotriol D05AX03 Calcitriol D05AX04 Tacalcitol D05AX05 Tazarotene D05AX06 Roflumilast D05AX07 Tapinarof D05AX52 Calcipotriol...

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WHO Model List of Essential Medicines for Children

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Corticosteroids, potent (group III)) Alternatives limited to calcitriol and tacalcitol Alternatives limited to podophyllotoxin Alternatives limited to precipitated...

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C27H44O3

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25-Dihydroxycholecalciferol Paricalcitol, an analog of vitamin D Sarsasapogenin Tacalcitol This set index page lists chemical structure articles associated with...

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Lithocholic acid

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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Lichen spinulosus

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emollients such as urea, adapalene, salicylic acid, vitamin A, tretinoin, and tacalcitol. Hook nail List of cutaneous conditions James, William; Berger, Timothy;...

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Paricalcitol

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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Doxercalciferol

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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Dihydrotachysterol

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Ergocalciferol (vitamin D2) Lithocholic acid Maxacalcitol Paricalcitol Tacalcitol Antagonists: ZK159222 TEI-9647 See also Receptor/signaling modulators...

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Erythromelanosis follicularis faciei et colli

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pigmentation. Topical therapies include metronidazole, ammonium lactate, tacalcitol ointment, retinoids, hydroquinone, and salicylic acid. There have been...

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