TXNIP information

TXNIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GEI, 4GEJ, 4GFX, 4LL1, 4LL4, 4ROF, 4ROJ, 5CQ2, 5DF6, 5DWS, 5DZD
Identifiers
Aliases	TXNIP, thioredoxin interacting protein, EST01027, HHCPA78, THIF, VDUP1, ARRDC6
External IDs	OMIM: 606599; MGI: 1889549; HomoloGene: 38186; GeneCards: TXNIP; OMA:TXNIP - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	145,996,579 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,469,199 bp
RNA expression pattern
	Top expressed in
	right lung; ; gastric mucosa; ; cardia; ; pericardium; ; skin of hip; ; renal medulla; ; deltoid muscle; ; canal of the cervix; ; nipple; ; glutes;
	Top expressed in
	right lung; ; submandibular gland; ; right lung lobe; ; masseter muscle; ; left lung; ; muscle of thigh; ; brown adipose tissue; ; left lung lobe; ; secondary oocyte; ; gastrula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	enzyme inhibitor activity; protein binding; ubiquitin protein ligase binding;
Cellular component	cytoplasm; cytosol; mitochondrial intermembrane space; nucleus;
Biological process	cellular response to tumor cell; response to estradiol; negative regulation of catalytic activity; regulation of transcription, DNA-templated; protein import into nucleus; response to progesterone; response to mechanical stimulus; negative regulation of transcription by RNA polymerase II; response to glucose; response to oxidative stress; transcription, DNA-templated; keratinocyte differentiation; response to calcium ion; negative regulation of cell division; regulation of cell population proliferation; positive regulation of apoptotic process; cell cycle; platelet-derived growth factor receptor signaling pathway; response to hydrogen peroxide; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	10628
	56338
	ENSG00000265972
	ENSMUSG00000038393
	Q9H3M7
	Q8BG60
	NM_006472; NM_001313972
	NM_001009935; NM_023719
	NP_001300901; NP_006463
	NP_001009935; NP_076208
	Wikidata
View/Edit Human	View/Edit Mouse

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000265972 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038393 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen KS, DeLuca HF (Sep 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1219 (1): 26–32. doi:10.1016/0167-4781(94)90242-9. PMID 8086474.
^ "Entrez Gene: TXNIP thioredoxin interacting protein".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000265972 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038393 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8086474-5] Chen KS, DeLuca HF (Sep 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1219 (1): 26–32. doi:10.1016/0167-4781(94)90242-9. PMID 8086474.

[entrez-6] "Entrez Gene: TXNIP thioredoxin interacting protein".

TXNIP information

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