TRPV4 information

TRPV4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DX1, 4DX2
Identifiers
Aliases	TRPV4, BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC, transient receptor potential cation channel subfamily V member 4
External IDs	OMIM: 605427; MGI: 1926945; HomoloGene: 11003; GeneCards: TRPV4; OMA:TRPV4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	109,833,406 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	114,796,482 bp
RNA expression pattern
	Top expressed in
	minor salivary glands; ; stromal cell of endometrium; ; oocyte; ; kidney; ; tibia; ; bronchial epithelial cell; ; skin of abdomen; ; right lobe of liver; ; secondary oocyte; ; parotid gland;
	Top expressed in
	proximal tubule; ; kidney; ; lip; ; nasal septum; ; lesser wing of sphenoid bone; ; membranous bone; ; rib; ; maxilla; ; human mandible; ; stria vascularis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; stretch-activated, cation-selective, calcium channel activity; osmosensor activity; microtubule binding; alpha-tubulin binding; SH2 domain binding; calmodulin binding; actin filament binding; ion channel activity; protein binding; beta-tubulin binding; cation channel activity; actin binding; ATP binding; protein kinase binding; protein kinase C binding; calcium channel activity; lipid binding; identical protein binding; metal ion binding;
Cellular component	integral component of membrane; cell projection; membrane; focal adhesion; filopodium; growth cone; adherens junction; plasma membrane; ruffle membrane; cell surface; cell junction; apical plasma membrane; cortical actin cytoskeleton; cytoplasmic microtubule; cytoplasmic vesicle; lamellipodium; integral component of plasma membrane; cilium; endoplasmic reticulum;
Biological process	actin cytoskeleton reorganization; cell volume homeostasis; cellular response to heat; positive regulation of inflammatory response; negative regulation of neuron projection development; glucose homeostasis; cellular hypotonic salinity response; positive regulation of chemokine (C-X-C motif) ligand 1 production; positive regulation of cytosolic calcium ion concentration; calcium ion import; positive regulation of monocyte chemotactic protein-1 production; response to mechanical stimulus; negative regulation of brown fat cell differentiation; osmosensory signaling pathway; cellular calcium ion homeostasis; hyperosmotic salinity response; microtubule polymerization; negative regulation of transcription by RNA polymerase II; positive regulation of JNK cascade; cellular hypotonic response; ion transport; vasopressin secretion; cellular response to osmotic stress; regulation of response to osmotic stress; diet induced thermogenesis; response to osmotic stress; response to insulin; positive regulation of gene expression; positive regulation of vascular permeability; calcium ion transmembrane transport; cortical microtubule organization; positive regulation of chemokine (C-C motif) ligand 5 production; cell-cell junction assembly; positive regulation of ERK1 and ERK2 cascade; hypotonic response; positive regulation of macrophage inflammatory protein 1 alpha production; blood vessel endothelial cell delamination; multicellular organismal water homeostasis; positive regulation of macrophage chemotaxis; calcium ion transport; positive regulation of microtubule depolymerization; actin filament organization; transmembrane transport; cartilage development involved in endochondral bone morphogenesis; energy homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	59341
	63873
	ENSG00000111199
	ENSMUSG00000014158
	Q9HBA0
	Q9EPK8
	NM_001177428; NM_001177431; NM_001177433; NM_021625; NM_147204
	NM_022017
	NP_001170899; NP_001170902; NP_001170904; NP_067638; NP_671737
	NP_071300
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel subfamily V member 4 is an ion channel protein that in humans is encoded by the TRPV4 gene.

The TRPV4 gene encodes TRPV4, initially named "vanilloid-receptor related osmotically activated channel" (VR-OAC) and "OSM9-like transient receptor potential channel, member 4 (OTRPC4)",^[5]^[6] a member of the vanilloid subfamily in the transient receptor potential (TRP) superfamily of ion channels.^[7]^[8]^[9] The encoded protein is a Ca²⁺-permeable, nonselective cation channel that has been found involved in multiple physiologic functions, dysfunctions and also disease. It functions in the regulation of systemic osmotic pressure by the brain, in vascular function, in liver, intestinal, renal and bladder function, in skin barrier function and response of the skin to ultraviolet-B radiation, in growth and structural integrity of the skeleton, in function of joints, in airway- and lung function, in retinal and inner ear function, and in pain. The channel is activated by osmotic, mechanical and chemical cues. It also responds to thermal changes (warmth). Channel activation can be sensitized by inflammation and injury.

The TRPV4 gene has been co-discovered by W. Liedtke et al.^[5] and R. Strotmann et al.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111199 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000014158 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Liedtke W, Choe Y, Martí-Renom MA, Bell AM, Denis CS, Sali A, et al. (October 2000). "Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor". Cell. 103 (3): 525–535. doi:10.1016/S0092-8674(00)00143-4. PMC 2211528. PMID 11081638.
^ ^a ^b Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD (October 2000). "OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity". Nature Cell Biology. 2 (10): 695–702. doi:10.1038/35036318. PMID 11025659. S2CID 21148080.
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–450. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
^ Harteneck C, Plant TD, Schultz G (April 2000). "From worm to man: three subfamilies of TRP channels". Trends in Neurosciences. 23 (4): 159–166. doi:10.1016/S0166-2236(99)01532-5. PMID 10717675. S2CID 41074873.
^ Plant TD, Strotmann R (2007). "TRPV4". Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology. Vol. 179. pp. 189–205. doi:10.1007/978-3-540-34891-7_11. ISBN 978-3-540-34889-4. PMID 17217058.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111199 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000014158 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11081638-5] Liedtke W, Choe Y, Martí-Renom MA, Bell AM, Denis CS, Sali A, et al. (October 2000). "Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor". Cell. 103 (3): 525–535. doi:10.1016/S0092-8674(00)00143-4. PMC 2211528. PMID 11081638.

[pmid11025659-6] Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD (October 2000). "OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity". Nature Cell Biology. 2 (10): 695–702. doi:10.1038/35036318. PMID 11025659. S2CID 21148080.

[pmid16382100-7] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–450. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

[pmid10717675-8] Harteneck C, Plant TD, Schultz G (April 2000). "From worm to man: three subfamilies of TRP channels". Trends in Neurosciences. 23 (4): 159–166. doi:10.1016/S0166-2236(99)01532-5. PMID 10717675. S2CID 41074873.

[pmid17217058-9] Plant TD, Strotmann R (2007). "TRPV4". Transient Receptor Potential (TRP) Channels. Handbook of Experimental Pharmacology. Vol. 179. pp. 189–205. doi:10.1007/978-3-540-34891-7_11. ISBN 978-3-540-34889-4. PMID 17217058.

TRPV4 information

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