Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000070985 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000009246 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Prawitt D, Enklaar T, Klemm G, Gärtner B, Spangenberg C, Winterpacht A, Higgins M, Pelletier J, Zabel B (January 2000). "Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression". Human Molecular Genetics. 9 (2): 203–16. doi:10.1093/hmg/9.2.203. PMID 10607831.
^Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene. TRPM5 is a calcium-activated...
permeability of calcium and magnesium varies widely among TRPM channels. TRPM4 and TRPM5 are impermeable to calcium. TRPM3, TRPM6 and TRPM7 are highly permeable...
endoplasmic reticulum. This increase in intracellular calcium activates the TRPM5 channel and induces cellular depolarization. The ATP release channel CALHM1...
others. βTRPMs include, but are not limited to, vertebrate TRPM2, TRPM4, TRPM5, and TRPM8 (the cold and menthol sensor). Two additional major clades have...
vision transduction. Additionally, taste receptors share the use of the TRPM5 ion channel, as well as a phospholipase PLCβ2. The TAS1R1+TAS1R3 heterodimer...
Ketoconazole has been found to inhibit the activity of the cation channel TRPM5. When administered orally, ketoconazole is best absorbed at highly acidic...
Calcium activates a so-called transient-receptor-potential cation channel TRPM5 that leads to membrane depolarization and the consequent release of ATP...
decreased neuronal response to oral fatty acids. Monovalent cation channel TRPM5 has been implicated in fat taste as well, but it is thought to be involved...
(PIP2) pathway. The nonselective cation Transient Receptor Potential channel TRPM5 has been shown to correlate with both umami and sweet taste. Also, the phospholipase...
transducing 3 Localization of G14 and G-gustducin in type II taste cells. TrpM5 is a cation channel of the TRP superfamily that is highly expressed in taste...
organ's specific functions. Tuft cells express chemosensory proteins, like TRPM5 and α-gustducin. These proteins indicate that neighbouring neurons can innervate...
trans-membrane taste receptors, the G-protein gustducin, PLCbeta2, IP3R3, TRPM5). Morphologically, the elements of the DCS are polymorphic. Some of them...
trans-membrane taste receptors, the G-protein gustducin, PLCbeta2, IP3R3, TRPM5). Usually, in chemosensory cluster a true "taste pore" is lacking. To date...
trans-membrane taste receptors, the G-protein gustducin, PLCbeta2, IP3R3, TRPM5). Morphologically, the elements of SCCs are polymorphic. Some of them have...
(PIP2) pathway. The nonselective cation Transient Receptor Potential channel TRPM5 has been shown to correlate with both umami and sweet taste. Also, the phospholipase...
Margolskee’s laboratory discovered the T1r3 sweet taste receptor in 2001 and the Trpm5 cation channel in 2002. Much of his current work is focused on 'taste cells...
for type I cells, α-gustducin, transient receptor potential melastatin 5 (TRPM5), and phospholipase C β2 (PLCβ2) for type II cells, and synaptosomal-associated...
known as transient receptor potential cation channel subfamily M member 5 (TRPM5). Ca2+-flux signaling assays are commonly used to measure the function of...
reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential...
Voets T, Ninomiya Y & Nilius B. (2008). The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions. FASEB J 22, 1343-1355 "Article"...
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