TLX2 information

TLX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3A03
Identifiers
Aliases	TLX2, HOX11L1, NCX, T-cell leukemia homeobox 2, T cell leukemia homeobox 2
External IDs	OMIM: 604240; MGI: 1350935; HomoloGene: 7575; GeneCards: TLX2; OMA:TLX2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	74,517,148 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,047,274 bp
RNA expression pattern
	Top expressed in
	transverse colon; ; rectum; ; duodenum; ; appendix; ; gastric mucosa; ; frontal lobe; ; prefrontal cortex; ; Brodmann area 9; ; body of stomach; ; fundus;
	Top expressed in
	adrenal medulla; ; autonomic nervous system; ; parasympathetic nervous system; ; female urethra; ; male urethra; ; autonomic ganglion; ; sympathetic nervous system; ; enteric nervous system; ; stellate ganglion; ; Greater petrosal nerve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	cytoplasm; nucleus; cellular component;
Biological process	multicellular organism development; enteric nervous system development; mesoderm formation; regulation of transcription, DNA-templated; negative regulation of dendrite morphogenesis; transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3196
	21909
	ENSG00000115297
	ENSMUSG00000068327
	O43763
	Q61663
	NM_016170; NM_001534
	NM_009392
	NP_057254
	NP_033418
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell leukemia homeobox protein 2 is a protein that in humans is encoded by the TLX2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115297 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068327 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puliti A, Cinti R, Betsos N, Romeo G, Ceccherini I (Jun 1999). "HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1→p12 and mouse chromosome 6C3-D1". Cytogenetics and Cell Genetics. 84 (1–2): 115–7. doi:10.1159/000015234. PMID 10343123. S2CID 21498122.
^ "Entrez Gene: TLX2 T-cell leukemia homeobox 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115297 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068327 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10343123-5] Puliti A, Cinti R, Betsos N, Romeo G, Ceccherini I (Jun 1999). "HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1→p12 and mouse chromosome 6C3-D1". Cytogenetics and Cell Genetics. 84 (1–2): 115–7. doi:10.1159/000015234. PMID 10343123. S2CID 21498122.

[entrez-6] "Entrez Gene: TLX2 T-cell leukemia homeobox 2".

TLX2 information

and 24 Related for: TLX2 information

TLX2

Transition metal

Boron group

List of human transcription factors

P53

Transcription factor

Myc

Zinc finger

Androgen receptor

CREB

Hormone receptor

Retinoblastoma protein

Nuclear receptor

Retinoid X receptor

Homeobox

Progesterone receptor

Glucocorticoid receptor

Sigma factor

Estrogen receptor

FOSB

General transcription factor

Corticosteroid receptor

Vitamin D receptor

Steroid hormone receptor