Chemical compound
Sunobinop Other names IMB-115 Drug class Nociceptin receptor agonist
4-[(1R,5S)-9-[(1S,5S)-3-bicyclo[3.3.1]nonanyl]-9-azabicyclo[3.3.1]nonan-3-yl]-3-oxoquinoxaline-2-carboxylic acid
CAS Number PubChem CID ChemSpider UNII ChEMBL Formula C 26 H 33 N 3 O 3 Molar mass 435.568 g·mol−1 3D model (JSmol)
O=C(O)C1=NC=2C=CC=CC2N(C1=O)C3CC4N(C(CCC4)C3)C5CC6CCCC(C5)C6
InChI=1S/C26H33N3O3/c30-25-24(26(31)32)27-22-9-1-2-10-23(22)29(25)21-14-18-7-4-8-19(15-21)28(18)20-12-16-5-3-6-17(11-16)13-20/h1-2,9-10,16-21H,3-8,11-15H2,(H,31,32)/t16-,17-,18-,19+,21?/m0/s1
Key:COTYYZPYDJKKIS-MCXOOUIESA-N
Sunobinop (developmental code names V117957 ; IMB-115 ) is a high affinity small molecule nociceptin receptor partial agonist.[1]
As of Feb 2024, it is under clinical investigation for the treatment of insomnia/alcohol use disorder, interstitial cystitis, and overactive bladder syndrome.[2] [3] It was previously also under investigation for the treatment of fibromyalgia.[1]
^ a b "Sunobinop - Shionogi/Imbrium Therapeutics". AdisInsight . Springer Nature Switzerland AG.
^ "Pipeline". Imbrium Therapeutics . Retrieved May 1, 2024 .
^ WO application 2018020418, Harris SC, Kapil RP, Kyle DJ, Whiteside G, "Treatment and prevention of sleep disorders", published 2018-02-01, assigned to Purdue Pharma L.P.
Last Update: 2024-05-13T05:42:40Z
Sunobinop (developmental code names V117957; IMB-115) is a high affinity small molecule nociceptin receptor partial agonist. As of Feb 2024, it is under...
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Last Update: 2024-06-15T16:22:11Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
Word Count : 11401
Last Update: 2024-06-10T17:47:39Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-06-15T19:47:59Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-06-11T16:06:33Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-02-26T09:27:45Z
melatonin receptor agonist and 5-HT1A and 5-HT1D receptor agonist [6] Sunobinop (IMB-115, IT-1315, S-117957, V-117957) – nociceptin receptor agonist [7][8]...
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Last Update: 2024-06-09T23:18:25Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-06-10T05:46:40Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-05-27T19:57:22Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-06-10T07:05:31Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-06-02T17:03:06Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-06-10T16:25:31Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-05-11T17:46:16Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-05-25T08:40:29Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-06-01T17:00:24Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-05-02T21:48:35Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-05-18T10:53:09Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-05-25T09:01:53Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-06-11T03:54:52Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-04-18T20:22:47Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-06-11T16:11:45Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-05-31T17:06:21Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-05-28T20:21:12Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-06-08T00:37:53Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-06-15T03:17:49Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
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Last Update: 2024-06-10T03:23:24Z
Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 Sunobinop (S-117957) TH-030418 Antagonists (Nphe1)Nociceptin(1-13)NH2 AT-076 BAN-ORL-24...
Word Count : 5314