NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)].[5][6] SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. SIRT3 exhibits NAD+-dependent deacetylase activity.
Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes, and the protein encoded by this gene is included in class I of the sirtuin family.[5] The human sirtuins have a range of molecular functions and have emerged as important proteins in aging, stress resistance, and metabolic regulation. Yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA.[7] In addition to protein deacetylation, studies have shown that the human sirtuins may also function as intracellular regulatory proteins with mono ADP ribosyltransferase activity.
^ abcGRCh38: Ensembl release 89: ENSG00000142082 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025486 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: SIRT3 sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)".
^Schwer B, North BJ, Frye RA, Ott M, Verdin E (August 2002). "The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase". Journal of Cell Biology. 158 (4): 647–57. doi:10.1083/jcb.200205057. PMC 2174009. PMID 12186850.
^Gartenberg MR, Smith JS (August 2016). "The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae". Genetics. 203 (4): 1563–1599. doi:10.1534/genetics.112.145243. PMC 4981263. PMID 27516616.
NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type...
Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. SIRT1 stands for sirtuin (silent...
Sirtuins are a family of signaling proteins involved in metabolic regulation. They are ancient in animal evolution and appear to possess a highly conserved...
NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent...
Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. In laboratory...
but are completely rescued by SARM1 deletion. Activation of NMNAT2 by Sirtuin3 (SIRT3) may be a means of inhibiting axon degeneration and dysfunction...
Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), also known as SIRT5 is a protein which in humans in encoded by the SIRT5...
studies). Suppression of insulin resistance by sirtuins accounts for at least some of this effect. Impaired sirtuin3 leads to mitochondrial dysfunction. Rapamycin...
(2018). "Regulatory Effects of NAD + Metabolic Pathways on Sirtuin Activity". Sirtuins in Health and Disease. Progress in Molecular Biology and Translational...
PMID 31903720. Li YH, Choi DH, Lee EH, Seo SR, Lee S, Cho EH (May 2016). "Sirtuin3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the...
NAD-dependent deacetylase sirtuin 7 is an enzyme that in humans is encoded by the SIRT7 gene. SIRT7 is member of the mammalian sirtuin family of proteins, which...
Sirtuin 4, also known as SIRT4, is a mitochondrial protein which in humans is encoded by the SIRT4 gene. SIRT4 is member of the mammalian sirtuin family...
found to be a potent sirtuin 6 (SIRT6) activator. Antirrhinin (cyanidin-3-rutinoside or 3-C-R), found in black raspberry Cyanidin-3-xylosylrutinoside, found...
level of stimulation can vary between individual fruits. Fisetin is a sirtuin-activating compound and has been shown in laboratory studies to extend...
endproducts inhibitory effects. It is also a sirtuin-activating compound, a chemical compound having an effect on sirtuins, a group of enzymes that use NAD+ to...
glucose tolerance. miR-34a represses the translation of sirtuin 1 (SIRT1) in liver by binding to the 3′-UTR region of SIRT1 messenger RNA, contributing to...
unsettled. Because NADH is a cofactor for processes inside mitochondria, for sirtuins and PARP, NMN has been studied in animal models as a potential neuroprotective...
insulin by binding to their PPAR receptors Agents that modulate sirtuins (called STAC –sirtuin-activating compounds), for example, fisetin Exanadin (exenatide)...
causes the upregulation of sirtuin 1 protein, which disrupts the transcription factor for AIM2, RelB. Knockdown of sirtuin 1 upregulates AIM2 expression...
deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., sirtuins). However, there are recent reports of the interactions of this molecule...
phosphate synthetase I (CPS I), interacts with a class of molecules called sirtuins, NAD dependent protein deacetylases, and ATP to form carbamoyl phosphate...
Guarente L (March 2014). "SIRT1 and other sirtuins in metabolism". Trends in Endocrinology and Metabolism. 25 (3): 138–145. doi:10.1016/j.tem.2013.12.001...
blocks are released from the vesicle through the action of permeases. Sirtuin 1 (SIRT1) stimulates autophagy by preventing acetylation of proteins (via...
to the sirtuin family, a broadly conserved family of NAD+-dependent protein deacetylases. CobB is a bacterial protein that belongs to the sirtuin family...
consequences. It arises through epigenetic modification (e.g., through HDAC, sirtuin, and G9a) and transcriptional regulation (primarily through ΔFosB's AP-1...
several co-repressors, including HDAC1 (histone deacetylase 1) and SIRT 1 (sirtuin 1). ... The net result is c-fos gene repression. Figure 4: Epigenetic basis...
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