Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication.[4] It is used along with exercise, diet, and weight loss to decrease elevated lipid levels.[4] It is also used to decrease the risk of heart problems in those at high risk.[4] It is taken by mouth.[4]
Common side effects include constipation, headaches, and nausea.[4] Serious side effects may include muscle breakdown, liver problems, and increased blood sugar levels.[4] A lower dose may be needed in people with kidney problems.[4] There is evidence of harm to the developing baby when taken during pregnancy[4][5] and it should not be used by those who are breastfeeding.[4] It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver.[4]
Simvastatin is made from the fungus Aspergillus terreus.[6] It was patented by Merck in 1980, and came into medical use in 1992.[6][7] Simvastatin is available as a generic medication,[4] and is on the World Health Organization's List of Essential Medicines.[8] In 2021, it was the sixteenth most commonly prescribed medication in the United States, with more than 30million prescriptions.[9][10]
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Cite error: The named reference Zocor FDA label was invoked but never defined (see the help page).
^"Active substance: simvastatin" (PDF). List of nationally authorised medicinal products. European Medicines Agency. 26 November 2020.
^ abcdefghijk"Simvastatin". The American Society of Health-System Pharmacists. Archived from the original on 10 January 2015. Retrieved 8 January 2015.
^"Prescribing medicines in pregnancy database". Australian Government. 3 March 2014. Archived from the original on 8 April 2014. Retrieved 22 April 2014.
^ abCechinel-Filho V (2012). Plant bioactives and drug discovery : principles, practice, and perspectives. Hoboken, N.J.: John Wiley & Sons. p. 104. ISBN 9780470582268. Archived from the original on 5 March 2016.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 472. ISBN 9783527607495.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Simvastatin - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. It is used along with exercise, diet, and...
pravastatin, rosuvastatin, and simvastatin. Combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available. The class...
The Scandinavian Simvastatin Survival Study (also known as the 4S study), was a multicentre, randomized, double-blind, placebo-controlled clinical trial...
of simvastatin, a lipid-lowering agent, are given with amlodipine, the risk of myopathy increases. The FDA issued a warning to limit simvastatin to a...
via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit...
taken by mouth. It is also available in the fixed combinations ezetimibe/simvastatin, ezetimibe/atorvastatin, ezetimibe/rosuvastatin, and ezetimibe/bempedoic...
milligram-equivalent doses of atorvastatin and milligram-equivalent or higher doses of simvastatin and pravastatin. Meta-analysis showed that rosuvastatin is able to modestly...
treatment or placebo at reducing the risk of CI-AKI. Statins (predominantly simvastatin) have been evaluated in clinical trials in combination with fibrates...
United Kingdom. It studied the use of the cholesterol lowering drug, simvastatin 40 mg and vitamin supplementation (vitamin E, vitamin C and beta carotene)...
Administration is recommending that physicians restrict prescribing high-dose Simvastatin (Zocor, Merck) to patients, given an increased risk of muscle damage...
Journal of Medicine. Polycap combines 100 milligrams of aspirin, with simvastatin (a generic version of Zocor, the cholesterol-lowering statin; 20 mg)...
codes not present in this list, which follows the WHO version. C10AA01 Simvastatin C10AA02 Lovastatin C10AA03 Pravastatin C10AA04 Fluvastatin C10AA05 Atorvastatin...
A noted drug interaction involves erythromycin and simvastatin, resulting in increased simvastatin levels and the potential for rhabdomyolysis. Another...
kidney failure or death, when simvastatin is used with amiodarone. This interaction is dose-dependent with simvastatin doses exceeding 20 mg. This drug...
Vytorin Efficacy International Trial): Comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute...
characteristic side effects for statins, can also occur. Contrary to lovastatin, simvastatin and atorvastatin, fluvastatin has no relevant interactions with drugs...
combinations of sitagliptin/metformin (Janumet, Janumet XR) and sitagliptin/simvastatin (Juvisync). Sitagliptin should not be used to treat type 1 diabetes....
with coronary heart disease: the Scandinavian Simvastatin Survival Study Authors: The Scandinavian Simvastatin Survival Study Group. Publication data: Lancet...
chlordiazepoxide, diazepam, and alprazolam Statins: lovastatin, pravastatin, and simvastatin Pharmaceuticals may also be described as "specialty", independent of...
Extended release niacin was combined with lovastatin (Advicor), and with simvastatin (Simcor), as prescription drug combinations. The combination niacin/lovastatin...
Statins that belong to this group are: Lovastatin (Figure 2) Pravastatin Simvastatin Type 2 statins Statins that are fully synthetic and have larger groups...
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