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Sesquiterpene lactone information


Sesquiterpene lactones (SLs) are a class of sesquiterpenoids that contain a lactone ring. They are most often found in plants of the family Asteraceae (daisies, asters). Other plant families with SLs are Umbelliferae (celery, parsley, carrots) and Magnoliaceae (magnolias). A collection of colorless, lipophilic solids, SLs are a rich source of drugs.[1] They can be allergenic and toxic in grazing livestock[2] causing severe neurological problems in horses. Some are also found in corals of the order Alcyonacea.

  1. ^ Ghantous, Akram; Gali-Muhtasib, Hala; Vuorela, Heikki; Saliba, Najat A.; Darwiche, Nadine (2010). "What Made Sesquiterpene Lactones Reach Cancer Clinical Trials?". Drug Discovery Today. 15 (15–16): 668–678. doi:10.1016/0305-1978(86)90101-8. PMID 20541036.
  2. ^ "Sesquiterpene Lactones and their toxicity to livestock". Cornell CALS. Cornell University. Retrieved December 29, 2018.

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Sesquiterpene lactone

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Sesquiterpene lactones (SLs) are a class of sesquiterpenoids that contain a lactone ring. They are most often found in plants of the family Asteraceae...

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Sesquiterpene

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provides the sesquiterpenoid farnesol. Sesquiterpene lactones are a common class of sesquiterpenoids that contain a lactone ring, hence the name. They are found...

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Ambrosia artemisiifolia

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economists, and atmospheric and agricultural modellers. Three sesquiterpene lactones isolated from the aerial parts of Ambrosia artemisiifolia were identified...

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Artemisinin

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efficient than using the plant. Artemisinin and its derivatives are all sesquiterpene lactones containing an unusual peroxide bridge. This endoperoxide 1,2,4-trioxane...

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Lactucopicrin

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analgesic effect, acting on the central nervous system. It is a sesquiterpene lactone, and is a component of lactucarium, derived from the plant Lactuca...

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Helenalin

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4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione, is a toxic sesquiterpene lactone which can be found in several plants such as Arnica montana and...

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Arglabin

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Arglabin is a sesquiterpene lactone belonging to the guaianolide subclass bearing a 5,7,5-tricyclic ring system which is known to inhibit farnesyl transferase...

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Parthenin

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Parthenin is a chemical compound classified as a sesquiterpene lactone. It has been isolated from Parthenium hysterophorus. It is genotoxic, allergenic...

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Costunolide

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(+)-Costunolide is a naturally occurring sesquiterpene lactone, first isolated in Saussurea costus roots in 1960. It is also found in lettuce. It is synthesized...

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Artemisin

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Artemisin is a sesquiterpene lactone, similar in structure to α-santonin. Artemisia (genus), hardy herbaceous plants and shrubs known for the powerful...

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Asteraceae

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commonly featured in medical and phytochemical journals because the sesquiterpene lactone compounds contained within them are an important cause of allergic...

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Parthenolide

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Parthenolide is a sesquiterpene lactone of the germacranolide class which occurs naturally in the plant feverfew (Tanacetum parthenium), after which it...

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Rhaponticum repens

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caused in horses ingesting Russian knapweed for prolonged periods. A sesquiterpene lactone, repin, in the plant is likely responsible for this toxicity. The...

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Absinthin

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absinthium. Absinthin's (1) complex structure is classified as a sesquiterpene lactone, meaning it belongs to a large category of natural products chemically...

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Artemisia annua

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artemether to be an effective antimalarial drug. Artemisinin is a sesquiterpene lactone with an endoperoxide bridge and has been produced as an antimalarial...

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Helenium amarum

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(1975). Toxicity and milk bittering properties of tenulin, the major sesquiterpene lactone constituent of Helenium amarum (bitter sneezeweed). J Agric Food...

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Xanthatin

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Xanthium strumarium (Asteracae) plant. It is classified as a natural sesquiterpene lactone. Xanthatin is believed to have anti-inflammatory, anti-tumour, anti-microbial...

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Magnolia grandiflora

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bacteria and fungi. The leaves contain coumarins and sesquiterpene lactones. The sesquiterpenes are known to be costunolide, parthenolide, costunolide...

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Guaianolide

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In organic chemistry, a guaianolide is a type of sesquiterpene lactone consisting of a gamma-lactone and either a cyclopentane or cyclopentene, both fused...

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Lactucin

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that forms a white crystalline solid and belongs to the group of sesquiterpene lactones. It is found in some varieties of lettuce and is an ingredient of...

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Artemisia vulgaris

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phenolic acids, coumarins, sterols, carotenoids, vitamins, and sesquiterpene lactones, among many others. Examples of the phytochemicals include vulgarin...

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C15H18O4

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C15H18O4 may refer to: Artemisin, a sesquiterpene lactone Helenalin, a sesquiterpene lactone Parthenin, a sesquiterpene lactone Plicatin A, a hydroxycinnamic...

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Eupatorium cannabinum

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anti-inflammatory agent for respiratory tract diseases, and several of its sesquiterpene lactone constituents were identified to have anti-inflammatory effect in...

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Chicory

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which contribute to the plant's bitterness are primarily the two sesquiterpene lactones, lactucin and lactucopicrin. Other components are aesculetin, aesculin...

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Lactarius torminosus

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consume the mushroom. The lactarane-type sesquiterpene lactone 15-hydroxyblennin A is one of several sesquiterpenes produced by the species. Other lactaranes...

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Artemisia afra

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10 minutes. After that, it is strained and mixed with honey. A sesquiterpene lactone from afra had cytotoxicity. It has a lot of genetic variation, especially...

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Cnicin

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Cnicin is a sesquiterpene lactone, esterified with a substituted acrylic acid, and belonging to the germacranolide class of natural products. It is mainly...

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Zoopharmacognosy

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triterpenes α- and β-amyrin, the eudesmane derivative β-selinene, and the sesquiterpene lactone 8β-hydroxyasterolide. Domestic cats and dogs often select and ingest...

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Sclareolide

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Sclareolide is a sesquiterpene lactone natural product derived from various plant sources including Salvia sclarea, Salvia yosgadensis, and cigar tobacco...

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