Candida albicans visualized using scanning electron microscopy. Note the abundant hyphal mass.
Scientific classification
Domain:
Eukaryota
Kingdom:
Fungi
Division:
Ascomycota
Class:
Saccharomycetes
Order:
Saccharomycetales
Family:
Saccharomycetaceae
Genus:
Candida
Species:
C. albicans
Binomial name
Candida albicans
(C.-P. Robin) Berkhout (1923)
Synonyms
Candida stellatoidea[1]
Monilia albicans[2]
Oidium albicans[3]
and many others.[4]
Candida albicans is an opportunistic pathogenic yeast[5] that is a common member of the human gut flora. It can also survive outside the human body.[6][7] It is detected in the gastrointestinal tract and mouth in 40–60% of healthy adults.[8][9] It is usually a commensal organism, but it can become pathogenic in immunocompromised individuals under a variety of conditions.[9][10] It is one of the few species of the genus Candida that cause the human infection candidiasis, which results from an overgrowth of the fungus.[9][10] Candidiasis is, for example, often observed in HIV-infected patients.[11]C. albicans is the most common fungal species isolated from biofilms either formed on (permanent) implanted medical devices or on human tissue.[12][13]C. albicans, C. tropicalis, C. parapsilosis, and C. glabrata are together responsible for 50–90% of all cases of candidiasis in humans.[10][14][15] A mortality rate of 40% has been reported for patients with systemic candidiasis due to C. albicans.[16] By one estimate, invasive candidiasis contracted in a hospital causes 2,800 to 11,200 deaths yearly in the US.[14] Nevertheless, these numbers may not truly reflect the true extent of damage this organism causes, given new studies indicating that C. albicans can cross the blood–brain barrier in mice.[17][18]
C. albicans is commonly used as a model organism for fungal pathogens.[19] It is generally referred to as a dimorphic fungus since it grows both as yeast and filamentous cells. However, it has several different morphological phenotypes including opaque, GUT, and pseudohyphal forms.[20][21]C. albicans was for a long time considered an obligate diploid organism without a haploid stage. This is, however, not the case. Next to a haploid stage C. albicans can also exist in a tetraploid stage. The latter is formed when diploid C. albicans cells mate when they are in the opaque form.[22] The diploid genome size is approximately 29 Mb, and up to 70% of the protein coding genes have not yet been characterized.[23]C. albicans is easily cultured in the lab and can be studied both in vivo and in vitro. Depending on the media different studies can be done as the media influences the morphological state of C. albicans. A special type of medium is CHROMagar Candida, which can be used to identify different Candida species.[24][25]
^Candida albicans at NCBI Taxonomy browser Archived 2018-12-15 at the Wayback Machine, url accessed 2006-12-26
^Cite error: The named reference The yeasts was invoked but never defined (see the help page).
^Saygin D, Tabib T, Bittar HE, Valenzi E, Sembrat J, Chan SY, et al. (May 1952). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary Circulation. 10 (1): 137–164. doi:10.2307/2394509. JSTOR 2394509. PMC 7052475. PMID 32166015.
^"Synonymy of Candida albicans". speciesfungorum.org. Archived from the original on 8 December 2021. Retrieved 8 December 2021.
^Gow NA, Yadav B (August 2017). "Microbe Profile: Candida albicans: a shape-changing, opportunistic pathogenic fungus of humans". Microbiology. 163 (8): 1145–1147. doi:10.1099/mic.0.000499. hdl:2164/12360. PMID 28809155.
^Bensasson D, Dicks J, Ludwig JM, Bond CJ, Elliston A, Roberts IN, James SA (January 2019). "Diverse Lineages of Candida albicans Live on Old Oaks". Genetics. 211 (1): 277–288. doi:10.1534/genetics.118.301482. PMC 6325710. PMID 30463870.
^Odds FC (1988). Candida and Candidosis: A Review and Bibliography (2nd ed.). London; Philadelphia: Bailliere Tindall. ISBN 978-0702012655.
^Kerawala C, Newlands C, eds. (2010). Oral and maxillofacial surgery. Oxford: Oxford University Press. pp. 446, 447. ISBN 978-0-19-920483-0.
^ abcErdogan A, Rao SS (April 2015). "Small intestinal fungal overgrowth". Current Gastroenterology Reports. 17 (4): 16. doi:10.1007/s11894-015-0436-2. PMID 25786900. S2CID 3098136.
^ abcCite error: The named reference pmid24789109 was invoked but never defined (see the help page).
^Cite error: The named reference Calderone was invoked but never defined (see the help page).
^Kumamoto CA (December 2002). "Candida biofilms". Current Opinion in Microbiology. 5 (6): 608–611. doi:10.1016/s1369-5274(02)00371-5. PMID 12457706.
^ abPfaller MA, Diekema DJ (January 2007). "Epidemiology of invasive candidiasis: a persistent public health problem". Clinical Microbiology Reviews. 20 (1): 133–163. doi:10.1128/CMR.00029-06. PMC 1797637. PMID 17223626.
^Schlecht LM, Peters BM, Krom BP, Freiberg JA, Hänsch GM, Filler SG, et al. (January 2015). "Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue". Microbiology. 161 (Pt 1): 168–181. doi:10.1099/mic.0.083485-0. PMC 4274785. PMID 25332378.
^Singh R, Chakrabarti A (2017). "Invasive Candidiasis in the Southeast-Asian Region". In Prasad R (ed.). Candida albicans: Cellular and Molecular Biology (2 ed.). Switzerland: Springer International Publishing AG. p. 27. ISBN 978-3-319-50408-7.
^Wu Y, Du S, Johnson JL, Tung HY, Landers CT, Liu Y, et al. (January 2019). "Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits". Nature Communications. 10 (1): 58. Bibcode:2019NatCo..10...58W. doi:10.1038/s41467-018-07991-4. PMC 6320369. PMID 30610193.
^"Fungi cause brain infection and impair memory in mice". Archived from the original on 2023-11-20. Retrieved 2019-01-04.
^Kabir MA, Hussain MA, Ahmad Z (2012). "Candida albicans: A Model Organism for Studying Fungal Pathogens". ISRN Microbiology. 2012: 538694. doi:10.5402/2012/538694. PMC 3671685. PMID 23762753.
^Kadosh D (December 2019). "Regulatory mechanisms controlling morphology and pathogenesis in Candida albicans". Current Opinion in Microbiology. 52: 27–34. doi:10.1016/j.mib.2019.04.005. PMC 6874724. PMID 31129557.
^Basso V, d'Enfert C, Znaidi S, Bachellier-Bassi S (2019). "From Genes to Networks: The Regulatory Circuitry Controlling Candida albicans Morphogenesis". Fungal Physiology and Immunopathogenesis. Current Topics in Microbiology and Immunology. Vol. 422. pp. 61–99. doi:10.1007/82_2018_144. ISBN 978-3-030-30236-8. PMID 30368597.
^Hickman MA, Zeng G, Forche A, Hirakawa MP, Abbey D, Harrison BD, et al. (February 2013). "The 'obligate diploid' Candida albicans forms mating-competent haploids". Nature. 494 (7435): 55–59. Bibcode:2013Natur.494...55H. doi:10.1038/nature11865. PMC 3583542. PMID 23364695.
^"Candida albicans SC5314 Genome Snapshot/Overview". www.candidagenome.org. Archived from the original on 16 November 2018. Retrieved 27 March 2018.
^Sevilla MJ, Odds FC (November 1986). "Development of Candida albicans hyphae in different growth media--variations in growth rates, cell dimensions and timing of morphogenetic events". Journal of General Microbiology. 132 (11): 3083–3088. doi:10.1099/00221287-132-11-3083. PMID 3305781.
^Odds FC, Bernaerts R (August 1994). "CHROMagar Candida, a new differential isolation medium for presumptive identification of clinically important Candida species". Journal of Clinical Microbiology. 32 (8): 1923–1929. doi:10.1128/JCM.32.8.1923-1929.1994. PMC 263904. PMID 7989544.
Candidaalbicans is an opportunistic pathogenic yeast that is a common member of the human gut flora. It can also survive outside the human body. It is...
fevers, among other symptoms. More than 20 types of Candida may cause infection with Candidaalbicans being the most common. Infections of the mouth are...
from immunocompetent individuals. It is of the genus Candida, very closely related to Candidaalbicans but forming a distinct phylogenetic cluster in DNA...
of Candida species on the mucous membranes of the mouth. Candidaalbicans is the most commonly implicated organism in this condition. C. albicans is carried...
ultimately human biology in great detail. Other species of yeasts, such as Candidaalbicans, are opportunistic pathogens and can cause infections in humans. Yeasts...
wound and tissue infections in immunocompromised people. Unlike Candidaalbicans and Candida tropicalis, C. parapsilosis is not an obligate human pathogen...
Candidal intertrigo is an infection of the skin by Candidaalbicans, more specifically located between intertriginous folds of adjacent skin.: 309 Candidiasis...
effect against an infection caused by Candidaalbican blastoconidia. Unfortunately, the blastoconidia of Candidaalbicans enhances attachment to a host, which...
Adhesins also have other functions, such as mating and biofilm formation. Candidaalbicans can cause opportunistic oral and genital infections in humans. Hwp1...
advanced HIV receiving treatment for thrush or esophageal Candida infection). In C. albicans, resistance occurs by way of mutations in the ERG11 gene,...
not depend on outcrossing. Candidaalbicans is a diploid fungus that grows both as a yeast and as a filament. C. albicans is the most common fungal pathogen...
Staphylococcus aureus, or gradually when it is commonly caused by the fungus Candidaalbicans. The term is from Greek: παρωνυχία from para 'around', onyx 'nail'...
Pseudohyphae, chlamydospores and blastospores of Candida yeast. Chlamydospores of the yeast Candidaalbicans Fungi portal Conidium Resting spore Zygospore...
a fungal infection. Candidaalbicans is a kind of diploid yeast that commonly occurs among the human gut microflora. C. albicans is an opportunistic pathogen...
infection, irritation, or allergies. Infections include by fungi such as Candidaalbicans and bacteria such as Staph. aureus. Irritants include poorly fitting...
The KOH Test for Candidaalbicans, also known as a potassium hydroxide preparation or KOH prep, is a quick, inexpensive fungal test to differentiate dermatophytes...
to medicine, plant pathology, and industrial uses; examples include Candidaalbicans, a dimorphic, opportunistic human pathogen, Magnaporthe grisea, a plant...
but also pathogenic fungi such as Candidaalbicans induce neutrophils to form NETs that capture and kill C. albicans hyphal as well as yeast-form cells...
Phenotypic switching in Candidaalbicans is often used to refer to the epigenetic white-to-opaque switching system. C. albicans needs this switch for sexual...
Esophageal candidiasis is an opportunistic infection of the esophagus by Candidaalbicans. The disease usually occurs in patients in immunocompromised states...
successfully applied to study the epidemiology of C. albicans in the hospital as well as the diversity of C. albicans isolates obtained from diverse ecological niches...
blastoconidia). An example of a fungus that forms blastospores is Candidaalbicans. "blastospore definition - Dictionary - MSN Encarta". Archived from...
aromatic carbon atom. Aromatic alcohols are produced by the yeast Candidaalbicans. They are also found in beer. These molecules are quorum sensing compounds...