negative regulation of myosin-light-chain-phosphatase activity
I-kappaB kinase/NF-kappaB signaling
regulation of establishment of cell polarity
cortical actin cytoskeleton organization
regulation of establishment of endothelial barrier
actin cytoskeleton organization
protein localization to plasma membrane
G protein-coupled receptor signaling pathway
aortic valve morphogenesis
positive regulation of cardiac muscle hypertrophy
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of cell migration
positive regulation of connective tissue growth factor production
positive regulation of MAPK cascade
regulation of protein metabolic process
positive regulation of stress fiber assembly
negative regulation of biomineral tissue development
response to transforming growth factor beta
positive regulation of fibroblast growth factor production
regulation of angiotensin-activated signaling pathway
negative regulation of protein localization to lysosome
positive regulation of amyloid-beta formation
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
positive regulation of protein localization to early endosome
positive regulation of amyloid precursor protein catabolic process
positive regulation of connective tissue replacement
response to angiotensin
response to ischemia
negative regulation of gene expression
regulation of nervous system process
negative regulation of nitric oxide biosynthetic process
mRNA destabilization
blood vessel diameter maintenance
regulation of cellular response to hypoxia
cellular response to acetylcholine
mitotic cytokinesis
actomyosin structure organization
embryonic morphogenesis
regulation of cell junction assembly
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9475
19878
Ensembl
ENSG00000134318
ENSMUSG00000020580
UniProt
O75116
P70336
RefSeq (mRNA)
NM_004850 NM_001321643
NM_009072
RefSeq (protein)
NP_001308572 NP_004841
NP_033098
Location (UCSC)
Chr 2: 11.18 – 11.35 Mb
Chr 12: 16.89 – 16.99 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene.
[5]Fasudil is an inhibitor of ROCK protein.
^ abcGRCh38: Ensembl release 89: ENSG00000134318 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020580 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. Fasudil is an inhibitor of ROCK protein. The protein encoded by this...
coiled-coil kinase 2 (ROCK2; ROCK-II). Belumosudil binds to and inhibits the serine/threonine kinase activity of ROCK2. This inhibits ROCK2-mediated signaling...
Records. Melchiondo's second solo album under The Dean Ween Group moniker, rock2, was released on March 16, 2018. with Ween GodWeenSatan: The Oneness (1990)...
Pakistan YouTube (25 March 2017). "Chal Diye by QB and Ali Azmat #CornettoPopRock2". Retrieved 24 September 2017 – via YouTube. "LSA 2018 entertainment nominations...
SWE #10, US #28 CAN: Platinum, UK, US: Gold 1983 Malcolm McLaren Duck Rock2 UK #18 UK: Silver 1983 Steve Hackett Highly Strung UK #16 1983 Peter Gabriel...
multi-specific ATP competitive inhibitor of activity of ROCK1 (IC50 of 5 nM), ROCK2 (IC50 of 50 nM), MRCKα (IC50 of 10 nM) and MRCKβ (IC50 of 100 nM) kinases...
These compounds include SLx-2119 (KD025), an inhibitor to Rho kinase 2 (ROCK2) with possible potential in fibrotic disease and focal cerebral ischemia...
Mutdapilly1 Peak Crossing1 Pine Mountain Purga Rosewood South Ripley Spring Mountain Tallegalla Thagoona The Bluff Walloon White Rock2 Willowbank Woolshed...
for fibrosis, inflammation and metabolism based on selective targeting of ROCK2. "Professor Justin Stebbing - ARU". aru.ac.uk. ARU. Retrieved 2022-11-30...
YouTube (10 September 2017). "Jee Liya By Momina Mustehsan #CornettoPopRock2". Retrieved 11 September 2017 – via YouTube. Times Music (17 January 2019)...
Wellington... not easter... new artists!", along with a new logo that says "Rock2????". However mid-2009 it got changed to Rock22010 with no word on delays...
Producer/Engineer 2019 Son Of Stan Diamond Cuts Wizardvision Engineer 2018 Dean Ween Rock2 Schnitzel Records Engineer 2017 Happyness Write In Bar/None Records Mixer/Engineer...
Little Mulgrave Meringa Miriwinni Mount Peter Mount Sheridan Ngatjan1 Packers Camp Waugh Pocket White Rock2 Woopen Creek Wooroonooran3 Woree Wrights Creek...
subcellular localization. There is one other isoform of ROCK known as ROCK2. ROCK2 is located at 2p24 and is highly homologous with ROCK1 with an overall...
contains 7 exons. The SLC66A3 gene is neighbored by the genes ROCK2, C2orf50, and KCNF1. ROCK2 and C2orf50 are both located upstream of SLC66A3 whereas KCNF1...