Micrograph of a sebaceous carcinoma (left of image) metastatic to the parotid gland (right of image). H&E stain.
Specialty
Oncology, dermatology
Sebaceous carcinoma, also known as sebaceous gland carcinoma (SGc), sebaceous cell carcinoma, and meibomian gland carcinoma is an uncommon malignant cutaneous tumor.[1] Most are typically about 1.4 cm at presentation.[2] SGc originates from sebaceous glands in the skin and, therefore, may originate anywhere in the body where these glands are found. SGc can be divided into 2 types: periocular and extraocular. The periocular region is rich in sebaceous glands making it a common site of origin.[3][4] The cause of these lesions in the vast majority of cases is unknown. Occasional cases may be associated with Muir-Torre syndrome.[5] SGc accounts for approximately 0.7% of all skin cancers, and the incidence of SGc is highest in Caucasian, Asian, and Indian populations.[2][6] Due to the rarity of this tumor and variability in clinical and histological presentation, SGc is often misdiagnosed as an inflammatory condition or a more common neoplasm.[6] SGc is commonly treated with wide local excision or Mohs micrographic surgery, and the relative survival rates at 5 and 10 years are 92.72 and 86.98%, respectively.[6]
^Nelson, B. R.; Hamlet, K. R.; Gillard, M.; Railan, D.; Johnson, T. M. (July 1995). "Sebaceous carcinoma". Journal of the American Academy of Dermatology. 33 (1): 1–15, quiz 16–18. doi:10.1016/0190-9622(95)90001-2. ISSN 0190-9622. PMID 7601925.
^ abOwen, Joshua L.; Kibbi, Nour; Worley, Brandon; Kelm, Ryan C.; Wang, Jordan V.; Barker, Christopher A.; Behshad, Ramona; Bichakjian, Christopher K.; Bolotin, Diana; Bordeaux, Jeremy S.; Bradshaw, Scott H. (December 2019). "Sebaceous carcinoma: evidence-based clinical practice guidelines". The Lancet. Oncology. 20 (12): e699–e714. doi:10.1016/S1470-2045(19)30673-4. ISSN 1474-5488. PMID 31797796. S2CID 208621012.
^Shields, Jerry A.; Demirci, Hakan; Marr, Brian P.; Eagle, Ralph C.; Shields, Carol L. (March 2005). "Sebaceous carcinoma of the ocular region: a review". Survey of Ophthalmology. 50 (2): 103–122. doi:10.1016/j.survophthal.2004.12.008. ISSN 0039-6257. PMID 15749305.
^Callahan, Elizabeth F.; Appert, David L.; Roenigk, Randall K.; Bartley, George B. (August 2004). "Sebaceous carcinoma of the eyelid: a review of 14 cases". Dermatologic Surgery. 30 (8): 1164–1168. doi:10.1111/j.1524-4725.2004.30348.x. ISSN 1076-0512. PMID 15274713. S2CID 32425922.
^Cite error: The named reference :43 was invoked but never defined (see the help page).
^ abcKnackstedt T, Samie FH (August 2017). "Sebaceous Carcinoma: A Review of the Scientific Literature". Current Treatment Options in Oncology. 18 (8): 47. doi:10.1007/s11864-017-0490-0. PMID 28681210. S2CID 207322971.
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