CAB39 information

CAB39
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UPK, 1UPL, 2WTK, 3GNI, 4FZA, 4FZD, 4FZF, 4NZW, 4O27
Identifiers
Aliases	CAB39, MO25, CGI-66, calcium binding protein 39
External IDs	OMIM: 612174; MGI: 107438; HomoloGene: 69212; GeneCards: CAB39; OMA:CAB39 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	230,821,075 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	85,779,297 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; tibia; ; middle temporal gyrus; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; mucosa of sigmoid colon; ; palpebral conjunctiva; ; glutes; ; cartilage tissue; ; triceps brachii muscle;
	Top expressed in
	facial motor nucleus; ; muscle of thigh; ; anterior horn of spinal cord; ; plantaris muscle; ; transitional epithelium of urinary bladder; ; soleus muscle; ; extensor digitorum longus muscle; ; gastrocnemius muscle; ; parotid gland; ; tibialis anterior muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase activator activity; protein kinase activator activity; protein serine/threonine kinase activity; kinase binding; protein binding;
Cellular component	cytoplasm; cytosol; serine/threonine protein kinase complex; extracellular exosome; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen; protein-containing complex;
Biological process	intracellular signal transduction; protein heterooligomerization; signal transduction; cellular hypotonic response; positive regulation of protein serine/threonine kinase activity; negative regulation of potassium ion transmembrane transporter activity; positive regulation of peptidyl-threonine phosphorylation; peptidyl-serine phosphorylation; negative regulation of potassium ion transmembrane transport; activation of protein kinase activity; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	51719
	12283
	ENSG00000135932
	ENSMUSG00000036707
	Q9Y376
	Q06138
	NM_001130849; NM_001130850; NM_016289
	NM_133781; NM_001355046; NM_001355047
	NP_001124321; NP_001124322; NP_057373
	NP_598542; NP_001341975; NP_001341976
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium-binding protein 39 is a protein that in humans is encoded by the CAB39 gene.^[5]

The protein encoded by this gene associates with STK11 (Serine/Threonine Kinase 11) and STRAD (STE20-Related ADaptor protein).^[6] CAB39 enhances formation of STK11/STRAD complexes and stimulates STK11 catalytic activity. CAB39 may function as a scaffolding component of the STK11/STRAD complex and regulates STK11 activity and cellular localization.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135932 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036707 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CAB39 calcium binding protein 39".
^ ^a ^b Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR (October 2003). "MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". EMBO J. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473. PMID 14517248.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135932 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036707 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CAB39 calcium binding protein 39".

[pmid14517248-6] Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR (October 2003). "MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". EMBO J. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473. PMID 14517248.

CAB39 information

and 3 Related for: CAB39 information

CAB39

C5orf24

WNK4