S100A12 information

S100A12
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1E8A, 1GQM, 1ODB, 2M9G, 2WC8, 2WCB, 2WCE, 2WCF
Identifiers
Aliases	S100A12, CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6, S100 calcium binding protein A12, EN-RAGE
External IDs	OMIM: 603112; HomoloGene: 48361; GeneCards: S100A12; OMA:S100A12 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,375,621 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; monocyte; ; bone marrow; ; bone marrow cells; ; blood; ; right lung; ; periodontal fiber; ; spleen; ; upper lobe of left lung; ; gums;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; zinc ion binding; metal ion binding; protein binding; RAGE receptor binding; copper ion binding;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; extracellular region; cytoskeleton; nucleus; secretory granule lumen;
Biological process	mast cell activation; positive regulation of inflammatory response; positive regulation of MAP kinase activity; monocyte chemotaxis; immune system process; defense response to fungus; neutrophil chemotaxis; defense response to bacterium; positive regulation of NF-kappaB transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; xenobiotic metabolic process; innate immune response; inflammatory response; neutrophil degranulation; antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of other organism;
	Sources:Amigo / QuickGO
Orthologs
	6283
	n/a
	ENSG00000163221
	n/a
	P80511
	n/a
	NM_005621
	n/a
	NP_005612
	n/a
	Wikidata
View/Edit Human

S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12 gene.^[3]^[4] Human S100A12, also known as calgranulin C, was first described in 1995.^[5]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163221 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (December 1996). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590.
^ "Entrez Gene: S100A12 S100 calcium binding protein A12".
^ Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (December 1996). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163221 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8985590-3] Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (December 1996). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590.

[entrez-4] "Entrez Gene: S100A12 S100 calcium binding protein A12".

[5] Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (December 1996). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590.

S100A12 information

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S100A12

List of distinct cell types in the adult human body

Calgranulin

EF hand

S100 protein

S100A9

Epidermal differentiation complex

S100A11

S100A13