For the Irish language radio station (RnaG), see RTÉ Raidió na Gaeltachta.
RnaG sRNA
Predicted secondary structure and sequence conservation of RnaG small RNA
Identifiers
Rfam
RF02550
Other data
Domain(s)
Bacteria
SO
SO:0000077,SO:0000370
PDB structures
PDBe
RnaG is a small regulatory non-coding RNA encoded by the virulence plasmid of Shigella flexneri, a Gram-negative pathogenic bacterium that causes human bacillary dysentery. It is a first regulatory RNA characterised in S. flexneri. The RNA is 450 nucleotides long (which makes it one of the largest regulatory sRNAs) and it contains a region with specific secondary structure that interacts with icsA (virG) mRNA and forms a transcription terminator. Acting as antisense, RnaG is transcribed from the complementary strand of its target, icsA mRNA.[1]
The activity of the incA protein is crucial for spreading of the bacterial pathogen in the host cells.[2]
^Giangrossi M, Prosseda G, Tran CN, Brandi A, Colonna B, Falconi M (June 2010). "A novel antisense RNA regulates at transcriptional level the virulence gene icsA of Shigella flexneri". Nucleic Acids Research. 38 (10): 3362–3375. doi:10.1093/nar/gkq025. PMC 2879508. PMID 20129941.
^Bernardini ML, Mounier J, d'Hauteville H, Coquis-Rondon M, Sansonetti PJ (May 1989). "Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin". Proceedings of the National Academy of Sciences of the United States of America. 86 (10): 3867–3871. doi:10.1073/pnas.86.10.3867. PMC 287242. PMID 2542950.
RnaG is a small regulatory non-coding RNA encoded by the virulence plasmid of Shigella flexneri, a Gram-negative pathogenic bacterium that causes human...
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