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Riboflavin synthase information


Riboflavin synthase
Crystallographic structure of E. coli
riboflavin synthase.[1]
Identifiers
EC no.2.5.1.9
CAS no.9075-82-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
6,7-dimethyl-8-ribityllumazine synthase
Riboflavin synthase from S. pombe bound to carboxyethyllumazine.[2]
Identifiers
SymbolDMRL_synthase
PfamPF00885
InterProIPR002180
SCOP21rvv / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1c2y​, 1c41​, 1di0​, 1ejb​, 1hqk​, 1kyv​, 1kyx​, 1kyy​, 1kz1​, 1kz4​, 1kz6​, 1kz9​, 1nqu​, 1nqv​, 1nqw​, 1nqx​, 1rvv​, 1t13​, 1w19​, 1w29​, 1xn1​, 1zis​, 2a57​, 2a58​, 2a59​, 2c92​, 2c94​, 2c97​, 2c9b​, 2c9d​, 2f59​, 2i0f​, 2o6h​, 2obx​, 2vi5

Riboflavin synthase is an enzyme that catalyzes the final reaction of riboflavin biosynthesis. It catalyzes the transfer of a four-carbon unit from one molecule of 6,7-dimethyl-8-ribityllumazine onto another, resulting in the synthesis of riboflavin and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione:

(2) 6,7-dimethyl-8-ribityllumazine → riboflavin + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
  1. ^ PDB: 1i8d​; Liao DI, Wawrzak Z, Calabrese JC, Viitanen PV, Jordan DB (May 2001). "Crystal structure of riboflavin synthase". Structure. 9 (5): 399–408. doi:10.1016/S0969-2126(01)00600-1. PMID 11377200.
  2. ^ PDB: 1kzl​; Gerhardt S, Schott AK, Kairies N, Cushman M, Illarionov B, Eisenreich W, Bacher A, Huber R, Steinbacher S, Fischer M (October 2002). "Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine". Structure. 10 (10): 1371–81. doi:10.1016/S0969-2126(02)00864-X. PMID 12377123.

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Riboflavin synthase

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Riboflavin synthase is an enzyme that catalyzes the final reaction of riboflavin biosynthesis. It catalyzes the transfer of a four-carbon unit from one...

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Riboflavin

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are combined by the enzyme riboflavin synthase in a dismutation reaction. This generates one molecule of riboflavin and one of 5-amino-6-(D-ribitylamino)...

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Lumazine synthase

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biosynthesis of riboflavin (vitamin B2). Lumazine synthase is thus found in those organisms (plants, fungi and most microorganisms) which produce riboflavin. Depending...

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Transferase

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other molecules. An example of a prominent glycosyltransferase is lactose synthase which is a dimer possessing two protein subunits. Its primary action is...

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Pseudouridine

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domain related to the biosynthesis of riboflavin. The RluA and DRAP or deaminase domain related to riboflavin synthase have completely separate functions...

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Homocystinuria

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defects (cobalamin defects, methionine synthase deficiency, MTHFR) and vitamin deficiencies including riboflavin (vitamin B2), pyridoxal phosphate (vitamin...

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B vitamins

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referred to by B-number or by chemical name, such as B1 for thiamine, B2 for riboflavin, and B3 for niacin, while some are more commonly recognized by name than...

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Flavin adenine dinucleotide

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together would restore activity. Theorell confirmed the pigment to be riboflavin's phosphate ester, flavin mononucleotide (FMN) in 1937, which was the first...

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Methionine synthase

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Methionine synthase (MS, MeSe, MTR) is primarily responsible for the regeneration of methionine from homocysteine in most individuals. In humans it is...

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Mark Cushman

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hydrates. Stereoselective interaction with the light riboflavin synthase of Bacillus subtilis". The Journal of Organic Chemistry. 56 (15):...

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Kinase

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phosphoglycerate, riboflavin, dihydroxyacetone, shikimate, and many others. Riboflavin kinase catalyzes the phosphorylation of riboflavin to create flavin...

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BART superfamily

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Riboflavin Transporter (P-RFT) Family TC# 9.B.33 - The Sensor Histidine Kinase (SHK) Family TC# 9.B.34 - The Kinase/Phosphatase/Cyclic-GMP Synthase/Cyclic...

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Flavoprotein

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Flavoproteins are proteins that contain a nucleic acid derivative of riboflavin. These proteins are involved in a wide array of biological processes, including...

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List of biomolecules

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acid (vitamin C) Asparagine Aspartic acid Asymmetric dimethylarginine ATP synthase Atrial-natriuretic peptide (ANP) Auxin Avidin Azadirachtin A – C35H44O16...

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Biotin

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of Medicine (1998). "Biotin". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and...

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Thiamine

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of Medicine (1998). "Thiamin". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and...

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GHB receptor

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solute carrier family 52 member 2 (SLC52A2), it is also a transporter for riboflavin. The existence of a specific GHB receptor was predicted by observing the...

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Vitamin B6

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dependent on flavin mononucleotide (FMN) as a cofactor produced from riboflavin (vitamin B2). For degradation, in a non-reversible reaction, PLP is catabolized...

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Biophysical chemistry

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protein crystallization using the technique called "laser trapping". Riboflavin, or commonly, vitamin B2, has the ability to become a reactive species...

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Methanocaldococcus jannaschii

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Bacher; Markus Fischer (2003). "Biosynthesis of riboflavin in Archaea: 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii". European Journal...

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Vitamin B12

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Medicine (1998). "Vitamin B12". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and...

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Onion

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1-propenesulfenic acid, is rapidly acted on by a second enzyme, the lacrimatory factor synthase (LFS), producing the syn-propanethial-S-oxide. This gas diffuses through...

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Amaranth

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already evolved resistances to dinitroaniline herbicides and acetolactate synthase inhibitors. This makes the proper identification of Amaranthus species...

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