Recurrence of stenosis, a narrowing of a blood vessel
The phenomenon of vessel restenosis, an immune response to damaged tissue, is known to be a common adverse event and the Achilles heel of angioplasty and stenting. Reducing restenosis is one of the highest priorities in research and the development of new endovascular technologies. Restenosis rates of drug-eluting stents appear to be significantly lower than bare-metal stents, and research is underway to determine if drug-coated balloons also improve restenosis outcomes.
Restenosis is the recurrence of stenosis, a narrowing of a blood vessel, leading to restricted blood flow. Restenosis usually pertains to an artery or other large blood vessel that has become narrowed, received treatment to clear the blockage, and subsequently become re-narrowed. This is usually restenosis of an artery, or other blood vessel, or possibly a vessel within an organ.
Restenosis is a common adverse event of endovascular procedures. Procedures frequently used to treat vascular damage from atherosclerosis and related narrowing and re-narrowing (restenosis) of blood vessels include vascular surgery, cardiac surgery, and angioplasty.[1]
When a stent is used and restenosis occurs, this is called in-stent restenosis or ISR.[2] If it occurs following balloon angioplasty, this is called post-angioplasty restenosis or PARS. The diagnostic threshold for restenosis in both ISR and PARS is ≥50% stenosis.[3]
If restenosis occurs after a procedure, follow-up imaging is not the only way to initially detect compromised blood flow. Symptoms may also suggest or signal restenosis, but this should be confirmed by imaging. For instance, a coronary stent patient who develops restenosis may experience recurrent chest pain (angina) or have a minor or major heart attack (myocardial infarction), though they may not report it. This is why it is important that a patient comply with follow-up screenings and the clinician follows through with a thorough clinical assessment. But it is also important to note that not all cases of restenosis lead to clinical symptoms, nor are they asymptomatic.[3]
^Forgos, Richard N. (August 2004). "Restenosis After Angioplasty and Stenting".
^Bennett, M. R (2003). "In-Stent Stenosis: Pathology and Implications for the Development of Drug Eluting Stents". Heart. 89 (2): 218–24. doi:10.1136/heart.89.2.218. PMC 1767562. PMID 12527687.
^ abHamid, H; Coltart, J (2007). "'Miracle stents' - a future without restenosis". McGill Journal of Medicine. 10 (2): 105–11. PMC 2323487. PMID 18523610.
Restenosis is the recurrence of stenosis, a narrowing of a blood vessel, leading to restricted blood flow. Restenosis usually pertains to an artery or...
synonym, but is commonly used only in the context of aortic coarctation. Restenosis is the recurrence of stenosis after a procedure. Examples of vascular...
adverse reactions/effects of the dye used in the procedure, infection, restenosis, clotting, blood vessel damage, and bleeding at catheter insertion site...
to restenosis relative to vascular bypass or coronary artery bypass grafting. Drug-eluting balloon angioplasty has significantly less restenosis, late...
medication to prevent complications such as blood clot formation and restenosis (re-narrowing). Stenting is performed through a procedure called percutaneous...
to counteract restenosis. Restenosis is typically described by clinical trials in a binary approach, otherwise known as "binary restenosis" or just "binary...
has a use in cardiovascular drug-eluting stent technologies to inhibit restenosis.[medical citation needed] It is the 40-O-(2-hydroxyethyl) derivative of...
Paclitaxel is used as an antiproliferative agent for the prevention of restenosis (recurrent narrowing) of coronary and peripheral stents; locally delivered...
procedures have been plagued by restenosis due to the formation of endothelial tissue overgrowth at the lesion site. Restenosis is the body's response to the...
has a use in cardiovascular drug-eluting stent technologies to inhibit restenosis. It is produced by the bacterium Streptomyces hygroscopicus and was isolated...
villonodular synovitis, and prevention of keloid scar growth, vascular restenosis, and heterotopic ossification. The use of radiation therapy in non-malignant...
aggregation, tearing, arterial recoil, and restenosis. Thus, coronary artery stents were created to prevent restenosis after balloon dilation. There are three...
Statistical Review International Studies Review Israel Studies Review In-stent restenosis, recurrence of stenosis after stenting Plant-induced systemic resistance...
year) Interventional radiology Vascular surgery Catheter Cannula Stent Restenosis Lakhan SE, Kaplan A, Laird C, Leiter Y (2009). "The interventionalism...
to detect restenosis. Long-term follow-up data from patients undergoing PBMV indicates that up to 70–75% individuals can be free of restenosis 10 years...
by compressive or torsional forces, leading to stent fracture and/or restenosis. On the other hand, lithoplasty balloon angioplasty may represent a safe...
in-stent restenosis, in which a catheter is placed inside blood vessels, through which sources are inserted and removed. In treating In-stent restenosis (ISR)...
trial) by SmithKline Beecham in partnership with Kissei for prevention of restenosis after percutaneous transluminal coronary revascularization, but was not...
hyperplasia is the universal response of a vessel to injury. It is a restenosis and this is an important reason of late bypass graft failure, particularly...
Lange Christian (1 December 2012). "Paclitaxel-Coated Balloons Reduce Restenosis After Femoro-Popliteal Angioplasty". Circulation: Cardiovascular Interventions...
endothelial layer over the stent to protect against thrombus and minimize restenosis. The Genous Stent is a bio-engineered coronary stent coated with immobilized...
stents were previously used because they showed low rates of in-stent restenosis, but further investigation showed that they often impair endothelial function...
restenosis after angioplasty, and improved procedures continue to be sought. The drug-eluting stent, which releases chemicals that inhibit restenosis...
which reduces the chance of re-blockage in the treated area known as restenosis, and reduces the chances that another procedure is required. The Cypher...
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